Rabbit Anti-HLA-DRB1 Recombinant Antibody (clone R02-4K1) (CAT#: VS3-XY3381)
This is a recombinant rabbit antibody targeting the human HLA-DRB1 (Major histocompatibility complex, class II, DR beta 1), which typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_8_8.jpg
Figure 2 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_4_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_4_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, THP-1, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, THP-1, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human HLA-DRB1
- Species Reactivity
- Human
- Clone
- R02-4K1
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Multiple Sclerosis; Sarcoidosis 1
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- SS1; DRB1; HLA-DRB; HLA-DR1B
- Gene ID
- 3123
- UniProt ID
- P01911
- Long Name
- Major histocompatibility complex, class II, DR beta 1
- Cellular Localization
- Cell membrane, Lysosome membrane, Endoplasmic reticulum membrane
- Post Translation Modifications
- Ubiquitinated by MARCHF1 and MARCHF8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHCII. (P01911-DRB1_HUMAN)
Glycosylation at Asn48 (NX_P01911 [NX_P01911-1])
Ubiquitination at Lys254 (NX_P01911 [NX_P01911-1])
Glycosylation from GlyConnect DRB1_HUMAN (1369, 1370, 1371, 1372, 1373, 1374, 1375, 1376)
Glycosylation from GlyGen (P01911) 1 site
- Protein Refseq
- XP_024308321.1
- Function
- A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule.
In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "HLA-DRB1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1090z | Mouse Anti-HLA-DRB1 Recombinant Antibody (MOB-1090z) | WB, IHC, IF, FC | Mouse IgG2b, κ |
| MOB-0940CT | Recombinant Mouse anti-Human HLA-DRB1 Monoclonal antibody (5j245) | Cyt, FuncS | |
| HPAB-0023-YC | Human Anti-HLA-DRB1 Recombinant Antibody (clone huA33) | ELISA | Humanized IgG |
| HPAB-0024-YC | Human Anti-HLA-DRB1 Recombinant Antibody (clone de-immunized huA33) | ELISA | Humanized IgG |
| HPAB-0086-FY | Mouse Anti-HLA-DRB1 Recombinant Antibody (HPAB-0086-FY) | FC, WB, EM, Cyt | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1090z-F(E) | Recombinant Anti-Human HLA-DRB1 Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| HPAB-0023-YC-F(E) | Human Anti-HLA-DRB1 Recombinant Antibody (clone huA33); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0024-YC-F(E) | Human Anti-HLA-DRB1 Recombinant Antibody (clone de-immunized huA33); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0025-YC-F(E) | Human Anti-HLA-DRB1 Recombinant Antibody (clone HD4); Fab Fragment | Cyt, WB | Human Fab |
| HPAB-0026-YC-F(E) | Human Anti-HLA-DRB1 Recombinant Antibody (clone HD8); Fab Fragment | Cyt, WB | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1090z-S(P) | Recombinant Anti-Human HLA-DRB1 Antibody scFv Fragment | WB, FC, FuncS | scFv |
| HPAB-0023-YC-S(P) | Human Anti-HLA-DRB1 Recombinant Antibody (clone huA33); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0024-YC-S(P) | Human Anti-HLA-DRB1 Recombinant Antibody (clone de-immunized huA33); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0025-YC-S(P) | Human Anti-HLA-DRB1 Recombinant Antibody (clone HD4); scFv Fragment | Cyt, WB | Human scFv |
| HPAB-0086-FY-S(P) | Mouse Anti-HLA-DRB1 Recombinant Antibody; scFv Fragment (HPAB-0086-FY-S(P)) | WB | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-150 | Anti-Human HLA DR beta Recombinant Antibody (Apolizumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1623 | Rabbit Anti-HLA-DRB1 Recombinant Antibody (clone DS1623AB) | WB, IHC, ICC | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3346 | PE-DRB1*04:01/Human HLA-DRB1 (VYPEVTVYPAKT) MHC Tetramer | FCM |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-150 | Afuco™ Anti-HLA-DRB1 ADCC Recombinant Antibody (Apolizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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