Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
  • Home
  • HNRNPC
  • Rabbit Anti-HNRNPC Recombinant Antibody (VS3-CJ476)

Rabbit Anti-HNRNPC Recombinant Antibody (VS3-CJ476) (CAT#: VS3-CJ476)

This product is a rabbit antibody that recognizes human, mouse, rat, and zebrafish heterogeneous nuclear ribonucleoproteins C (C1/C2).


See more Engineered Antibody products for HNRNPC
Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5223/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75755/1894_G2_3_selected.jpg
Normal Tissue
Figure 3 IHC staining of human prostate
Figure 3 IHC staining of human prostate
(Immunohistochemical staining of human prostate shows strong nuclear positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5223/ihc_selected.jpg
Figure 4 IHC staining of human tonsil
Figure 4 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong nuclear positivity in germinal center cells and non-germinal center cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75755/159385_A_5_8_selected.jpg
Figure 5 Liver
Figure 5 Liver
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5223/13358_A_9_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5223/13358_A_9_5.jpg
Figure 7 Testis
Figure 7 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51075/124984_A_6_6.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51075/124984_A_7_8.jpg
Figure 9 Colon
Figure 9 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51075/124984_A_9_3.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Figure 10 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000092199-HNRNPC

Specifications

  • Immunogen
  • Recombinant protein
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse, Rat, Zebrafish heterogeneous nuclear ribonucleoproteins C (C1/C2)
  • Species Reactivity
  • Human, Mouse, Rat, Zebrafish
  • Applications
  • WB, ICC, IF, IHC, IP, FC
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Protein A affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 40% Glycerol, 1% BSA, TBS, pH7.4.
  • Preservative
  • 0.05% Sodium Azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Flow Cytometry.

Target

  • Alternative Names
  • C1; C2; HNRNP; HNRPC; SNRPC
  • Sequence Similarities
  • Belongs to the RRM HNRPC family. RALY subfamily.
  • Cellular Localization
  • Nucleus, Spliceosome
  • Post Translation Modifications
  • Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
    Sumoylated. Sumoylation reduces affinity for mRNA.
  • Function
  • Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621).
    Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).
    Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621).
    May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

Recommended Products

Isotype Control

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "HNRNPC"

Recombinant Antibody

CAT Product Name Application Type
MOB-0611CT Recombinant Mouse anti-Human HNRNPC Monoclonal antibody (5G5) ELISA, ICC/IF, IHC-P, IP, WB
MRO-0760-CN Rabbit Anti-HNRNPC Recombinant Antibody (clone CBACN-281) WB, IF, IHC, IP, FC Rabbit IgG
ZG-0741J Rabbit Anti-HNRNPC Recombinant Antibody (clone 9G1) ELISA, WB, IHC, IF, FC, IP Rabbit IgG
VS1-YJ99 Mouse Anti-HNRNPC Recombinant Antibody (clone 4F4) ELISA, IF, IHC-P, IP Mouse IgG1

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1580 PE-B*41:03/Human HNRNPC (AEMYGSVTEHPSPSPL) MHC Tetramer FCM
MHC-LC1581 APC-B*41:03/Human HNRNPC (AEMYGSVTEHPSPSPL) MHC Tetramer FCM
MHC-LC1582 BV421-B*41:03/Human HNRNPC (AEMYGSVTEHPSPSPL) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1646 Rabbit Anti-HNRNPC Recombinant Antibody (clone DS1646AB) WB, IHC-P, ICC Rabbit IgG

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for VS3-CJ476. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart
    Inquiry

    Go to compare