Recombinant Mouse Antibody clone 60.3, which is specific to CD18. mAb 60.3 interacts with the CD 18 component of the β2 integrins. 60.3 has potential clinical application in blocking the neutrophil-mediated organ damage which occurs following a myocardial infarct or hemorrhagic shock.
Figure 1 Comparison of in vitro adhesion by activated peripheral blood leukocytes from a cat affected by feline leukocyte adhesion deficiency and a control cat.
Purified leukocytes from the proband and control cat were bound to fibrinogen in the absence (No PMA) or presence of the CD11/CD18 activator phorbol 12-myristate 13-acetate (PMA). Adhesion of activated leukocytes was completely blocked by anti-CD18 antibody 60.3 in the control cat, demonstrating CD18 specificity. The vertical lines indicate the SD of triplicate data.
Bauer Jr, T. R., Pratt, S. M., Palena, C. M., Raj, K., & Giger, U. (2017). Feline leukocyte adhesion (CD 18) deficiency caused by a deletion in the integrin β2 (ITGB 2) gene. Veterinary clinical pathology, 46(3), 391-400.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-980 | Recombinant Mouse Anti-Human ITGB2 Antibody F(ab')2 Fragment, clone IB4 | FC, Inhib | F(ab')2 |
FAMAB-0203CQ-F(E) | Mouse Anti-ITGB2 Recombinant Antibody (clone 60.3); Fab Fragment | ELISA, WB, Block | Mouse Fab |
FAMAB-0204CQ-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone h60.3); Fab Fragment | ELISA, WB, Block | Human Fab |
HPAB-1376WJ-F(E) | Human Anti-ITGB2 Recombinant Antibody; Fab Fragment (clone huH52) | ELISA, WB | Human Fab |
HPAB-1569WJ-F(E) | Mouse Anti-ITGB2 Recombinant Antibody; Fab Fragment (clone 1B4) | ELISA, WB, IF | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NABG-099 | Recombinant Anti-Human ITGB2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-044 | Anti-Human ITGB2 Recombinant Antibody (Rovelizumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG4 |
TAB-461CL | Human Anti-ITGB2 Recombinant Antibody (TAB-461CL) | ELISA | Human IgG |
TAB-1582CL | Anti-Human ITGB2 Recombinant Antibody (Hu23F2G (also known as LeukArrest and Rovelizumab)) | IP, FuncS | Humanized antibody |
TAB-1582CL-S(P) | Anti-Human ITGB2 Recombinant Antibody scFv Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab)) | Inhib | Humanized antibody |
TAB-1582CL-F(E) | Anti-Human ITGB2 Recombinant Antibody Fab Fragment (Hu23F2G (also known as LeukArrest and Rovelizumab)) | Inhib | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1581CL | Anti-Human ITGB2 Recombinant Antibody (23F2G) | Inhib | |
TAB-1581CL-S(P) | Anti-Human ITGB2 Recombinant Antibody scFv Fragment (23F2G) | Inhib | |
TAB-1581CL-F(E) | Anti-Human ITGB2 Recombinant Antibody Fab Fragment (23F2G) | Inhib |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0298MZ | Chicken Anti-ITGB2 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1590CQ | Recombinant Mouse Anti-ITGB2 Antibody (MEM-48) | BL, FC, IHC-Fr, IHC-P, IP, WB | IgG1 |
NEUT-1591CQ | Recombinant Mouse Anti-ITGB2 Antibody (TS1/18) | BL, FC, ICC/IF, IHC, WB | IgG1 |
NEUT-1592CQ | Recombinant Mouse Anti-ITGB2 Antibody (YFC118.12) | FC, BL | IgG1, κ |
NEUT-1593CQ | Recombinant Mouse Anti-ITGB2 Antibody (MEM-148) | FC, IP, WB, BL, FuncS | IgG1 |
NEUT-1594CQ | Recombinant Hamster Anti-Itgb2 Antibody (2E6) | BL, ICC, IP, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1884 | Hi-Affi™ Recombinant Rabbit Anti-ITGB2 Monoclonal Antibody (DS1884AB) | IP, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0204CQ | Human Anti-ITGB2 Recombinant Antibody (clone h60.3) | ELISA, WB, Block | Humanized IgG1, κ |
MRO-0283-CN | Recombinant Rabbit Anti-ITGB2 Monoclonal Antibody (JM71-31) | WB, IP | Rabbit IgG |
HPAB-1874-FY | Human Anti-ITGB2 Recombinant Antibody (clone NA-8) | Block | Human IgG1 |
ZG-0374F | Mouse Anti-ITGB2 Recombinant Antibody (ZG-0374F) | IF, ELISA | Mouse IgG |
ZG-0719F | Mouse Anti-ITGB2 Recombinant Antibody (clone 3EB) | FC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-044 | Afuco™ Anti-ITGB2 ADCC Recombinant Antibody (Rovelizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1769-FY-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone D2-57); scFv Fragment | ELISA | Human scFv |
HPAB-1207WJ-S(P) | Human Anti-ITGB2 Recombinant Antibody (clone pxCD18-7T3); scFv Fragment | ELISA | Human scFv |
HPAB-1874-FY-F(E) | Human Anti-ITGB2 Recombinant Antibody (clone NA-8); scFv Fragment | Block | Humanized scFv |
HPAB-1376WJ-S(P) | Human Anti-ITGB2 Recombinant Antibody; scFv Fragment (clone huH52) | ELISA, WB | Human scFv |
HPAB-1569WJ-S(P) | Mouse Anti-ITGB2 Recombinant Antibody; scFv Fragment (clone 1B4) | ELISA, WB, IF | Mouse scFv |
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