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Mouse Anti-KLB Recombinant Antibody (clone A1); Fab Fragment (CAT#: HPAB-M0131-YC-F(E))

Provided is an antibody capable of being specifically combined with human beta-Klotho receptor. The antibody can be specifically combined with a co-receptor beta-Klotho of a fibroblast growth factor 21, is used for activating a human beta-Klotho/FGFR1c (Fibroblast Growth Factor Receptor 1c) complex receptor and can be used for treating or preventing type II diabetes mellitus and related diseases in mammals.


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Normal Tissue
Figure 1 IHC staining of human small intestine
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21136/ihc_selected.jpg
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21136/48772_B_9_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21136/48772_A_8_3.jpg
Figure 4 Liver
Figure 4 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21136/48772_A_8_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21136/48772_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21136/48772_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/21136/48772_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (ASC diff, Hep G2)
Figure 8 RNA cell line category: Group enriched (ASC diff, Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134962-KLB

Specifications

  • Immunogen
  • The CHO-DHFR-V5-hKLB whole cells
  • Host Species
  • Mouse
  • Type
  • Mouse Fab
  • Specificity
  • Human KLB
  • Species Reactivity
  • Human
  • Clone
  • A1
  • Applications
  • ELISA, FC

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Klotho Beta; Klotho Beta-Like Protein; BetaKlotho; B-Klotho; BKL; Klotho Beta Like; Beta-Klotho; EC 3.2.1;

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone A1"

See other products for "KLB"

Mouse Antibody

CAT Product Name Application Type
TAB-1251CL-S(P) Mouse Anti-KLB Recombinant Antibody; scFv Fragment (TAB-1251CL-S(P)) ELISA, FC, FuncS Mouse scFv
TAB-1252CL-S(P) Mouse Anti-KLB Recombinant Antibody; scFv Fragment (TAB-1252CL-S(P)) ELISA, FC Mouse scFv
TAB-1253CL-S(P) Mouse Anti-KLB Recombinant Antibody; scFv Fragment (TAB-1253CL-S(P)) ELISA, FC Mouse scFv
TAB-1254CL-S(P) Mouse Anti-KLB Recombinant Antibody; scFv Fragment (TAB-1254CL-S(P)) ELISA, FC Mouse scFv
TAB-1255CL-S(P) Mouse Anti-KLB Recombinant Antibody; scFv Fragment (TAB-1255CL-S(P)) ELISA, FC Mouse scFv

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0367-CN-S(P) Mouse Anti-KLB Recombinant Antibody; scFv Fragment (HPAB-0367-CN-S(P)) ELISA, FC, Block Mouse scFv
HPAB-0368-CN-S(P) Mouse Anti-KLB Recombinant Antibody; scFv Fragment (HPAB-0368-CN-S(P)) ELISA, FC Mouse scFv
PSBC-249 Human Anti-KLB Recombinant Antibody; scFv Fragment (PSBC-249) ELISA, FC, Agonist Human scFv
HPAB-M0132-YC-S(P) Mouse Anti-KLB Recombinant Antibody (clone A2); scFv Fragment ELISA, FC Mouse scFv
HPAB-M0133-YC-S(P) Mouse Anti-KLB Recombinant Antibody (clone A3); scFv Fragment ELISA, FC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0367-CN-F(E) Mouse Anti-KLB Recombinant Antibody; Fab Fragment (HPAB-0367-CN-F(E)) ELISA, FC, Block Mouse Fab
HPAB-0368-CN-F(E) Mouse Anti-KLB Recombinant Antibody; Fab Fragment (HPAB-0368-CN-F(E)) ELISA, FC Mouse Fab
HPAB-0369-CN-F(E) Mouse Anti-KLB Recombinant Antibody; Fab Fragment (HPAB-0369-CN-F(E)) ELISA, FC Mouse Fab
HPAB-0370-CN-F(E) Human Anti-KLB Recombinant Antibody; Fab Fragment (HPAB-0370-CN-F(E)) ELISA, FC Human Fab
HPAB-0371-CN-F(E) Human Anti-KLB Recombinant Antibody; Fab Fragment (HPAB-0371-CN-F(E)) ELISA, FC Human Fab

Recombinant Antibody

CAT Product Name Application Type
PABC-249 Human Anti-KLB Recombinant Antibody (PABC-249) ELISA, SPR, FC, Agonist Human IgG
HPAB-0263-WJ Mouse Anti-KLB Recombinant Antibody (HPAB-0263-WJ) Agonist Mouse IgG
HPAB-0264-WJ Mouse Anti-KLB Recombinant Antibody (HPAB-0264-WJ) Agonist Mouse IgG
HPAB-0265-WJ Mouse Anti-KLB Recombinant Antibody (HPAB-0265-WJ) Agonist Mouse IgG
HPAB-N0158-YC Human Anti-KLB Recombinant Antibody (HPAB-N0158-YC) FC, FuncS Humanized IgG

Single-domain Antibody

CAT Product Name Application Type
NBD-0088-YJ-VHH Camelid Anti-KLB Recombinant Single Domain Antibody (Nb30) ELISA Camelid VHH
NBD-0089-YJ-VHH Camelid Anti-KLB Recombinant Single Domain Antibody (Nb914) ELISA Camelid VHH

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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