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  • Human Anti-KRT8 Recombinant Antibody (clone COU-1); scFv Fragment

Human Anti-KRT8 Recombinant Antibody (clone COU-1); scFv Fragment (CAT#: FAMAB-0344JF-S(P))

Recombinant monoclonal antibody specially binds to modified cytokeratin 8 and 18 expressed on the surface of carcinoma cells. COU-1 is a human monoclonal antibody that can be widely used in imaging of colon, rectal, and pancreatic carcinomas in patients.


See more Engineered Antibody products for KRT8
Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49866/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/131/if_selected.jpg
Figure 3 IHC staining of human stomach
Figure 3 IHC staining of human stomach
(Immunohistochemical staining of human stomach, upper shows strong cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49866/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Figure 4 Colon
(Endocrine cells
Staining:

High

Intensity: Strong

Enterocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining:

High

Intensity: Strong

Goblet cells
Staining:

High

Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49866/117727_A_7_3.jpg
Figure 5 Liver
Figure 5 Liver
(Cholangiocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49866/117727_A_8_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in tubules
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49866/117727_A_8_5.jpg
Figure 7 Testis
Figure 7 Testis
(Spermatogonia cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49866/117727_A_5_6.jpg
Figure 8 Prostate
Figure 8 Prostate
(Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49866/117727_A_3_5.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2, CAPAN-2, MCF7, SK-BR-3, T-47d)
Figure 9 RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2, CAPAN-2, MCF7, SK-BR-3, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000170421-KRT8
Figure 9 RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2, CAPAN-2, MCF7, SK-BR-3, T-47d)
Figure 9 RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2, CAPAN-2, MCF7, SK-BR-3, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000170421-KRT8

Specifications

  • Host Species
  • Human
  • Type
  • Human scFv
  • Specificity
  • Human Cytokeratin 8, Cytokeratin 18
  • Species Reactivity
  • Human
  • Clone
  • COU-1
  • Applications
  • IHC, ELISA, FuncS
  • Related Disease
  • Colon carcinomas, Rectal carcinomas, Pancreatic carcinomas

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • K8; KO; CK8; CK-8; CYK8; K2C8; CARD2

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone COU-1"

See other products for "KRT8"

Recombinant Antibody

CAT Product Name Application Type
MOB-1179z Mouse Anti-KRT8 Recombinant Antibody (clone 20C2) FC, ICC, IF, IHC Mouse IgG1, κ
MRO-0452-CN Recombinant Mouse Anti-KRT8 Monoclonal Antibody (A1-B11) WB, IF, IHC, FC Mouse IgG1
MRO-1808-CN Rabbit Anti-KRT8 Polyclonal Antibody (MRO-1808-CN) WB, IF, IHC, FC Rabbit IgG
MRO-1809-CN Rabbit Anti-KRT8 Polyclonal Antibody (MRO-1809-CN) WB, IF, IHC, FC Rabbit IgG
HPAB-0199-WJ Mouse Anti-KRT8 Recombinant Antibody (clone 8G8) ELISA, IHC Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1993 Hi-Affi™ Recombinant Rabbit Anti-KRT8 Monoclonal Antibody (DS1993AB) IHC-P, IHC-Fr IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0199-WJ-S(P) Mouse Anti-KRT8 Recombinant Antibody (clone 8G8); scFv Fragment ELISA, IHC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0199-WJ-F(E) Mouse Anti-KRT8 Recombinant Antibody (clone 8G8); Fab Fragment ELISA, IHC Mouse Fab
FAMAB-0344JF-F(E) Human Anti-KRT8 Recombinant Antibody (clone COU-1); Fab Fragment IHC, ELISA, FuncS Human Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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