This product is a recombinant human antibody that recognizes PDGFRB. 1B3 binds to murine PDGFRβ but not human PDGFRβ
Figure 1 IMC-2C5 binds to human and mouse PDGFRβ and efficiently blocks PDGF-B/PDGFRβ interaction.
1B3, an antibody specific to mouse PDGFRβ, was used as a control. The binding activities of IMC-2C5 to immobilized human and mouse PDGFRβ were assayed by ELISA. (A) Binding to hPDGFRβ. (B) Binding to mPDGFRβ. (C) Blocking PDGF-B binding to hPDGFRβ. (D) Blocking PDGF-B binding to mPDGFRβ. Data represent the mean ± SD of triplicate determinations.
Shen, J., Vil, M. D., Prewett, M., Damoci, C., Zhang, H., & Li, H., et al. (2009). Development of a fully human anti-pdgfrβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-vegfr2 antibody. Neoplasia, 11(6), 594-604.
Figure 2 IMC-2C5 antibody inhibits tumor growth as a monotherapy agent in xenograft models.
nu/nu mice (female, 7-8 weeks) were injected subcutaneously with ∼5 × 106 tumor cells: OVCAR-8 (A), NCI-H460 (B), OVCAR-5 (C), or Caki-1 (D). When tumors reached 250 to 300 mm3, mice were randomized into two treatment groups (n = 10 or 12) following a treatment schedule: antibodies at 60 mg/kg twice weekly (A, C, and D) or three times a week at 40 mg/kg (B) by i.p. injection. Human IgG and USP saline were used as controls. Tumor volumes of mice were recorded twice a week. Results shown are the mean ± SEM.
Shen, J., Vil, M. D., Prewett, M., Damoci, C., Zhang, H., & Li, H., et al. (2009). Development of a fully human anti-pdgfrβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-vegfr2 antibody. Neoplasia, 11(6), 594-604.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1734z | Mouse Anti-PDGFRB Recombinant Antibody (clone 1H11) | ELISA, IF, WB | Mouse IgG1 |
MRO-1193-CN | Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (CBACN-438) | WB, IHC, IP | Rabbit IgG |
MRO-2356-CN | Recombinant Rabbit Anti-PDGFRB (phosphorylated Tyr740) Monoclonal Antibody (CBACN-645) | WB, IF | Rabbit IgG |
HPAB-N0227-YC | Human Anti-PDGFRB Recombinant Antibody (clone PFH2) | Block | Human IgG |
HPAB-1110-CN | Mouse Anti-PDGFRB Recombinant Antibody (HPAB-1110-CN) | ELISA | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-706CL | Anti-Human PDGFRB Therapeutical Antibody (IMC-2C5) | Inhib, FuncS | Antibody |
TAB-0988CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0988CL) | ELISA | Human IgG |
TAB-0989CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0989CL) | ELISA | Human IgG |
TAB-0990CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0990CL) | ELISA | Human IgG |
TAB-0991CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0991CL) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1850CQ | Recombinant Rat Anti-Pdgfrb Antibody (APB5) | FC, FuncS, Neut | IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2638 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (DS2638AB) | WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0281CQ-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); Fab Fragment | ELISA, FC, WB, Neut | Human Fab |
HPAB-1110-CN-F(E) | Mouse Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1110-CN-F(E)) | ELISA | Mouse Fab |
HPAB-1111-CN-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1111-CN-F(E)) | ELISA | Human Fab |
HPAB-1112-CN-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1112-CN-F(E)) | ELISA | Human Fab |
HPAB-1113-CN-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1113-CN-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0281CQ-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); scFv Fragment | ELISA, FC, WB, Neut | Human scFv |
HPAB-S0105-YC-S(P) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11); scFv Fragment | ELISA, Neut | Mouse scFv |
HPAB-S0106-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11); scFv Fragment | ELISA, Neut | Humanized scFv |
HPAB-S0107-YC-S(P) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22); scFv Fragment | ELISA, Neut | Mouse scFv |
HPAB-S0108-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.22); scFv Fragment | ELISA, Neut | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-448CQ | Afuco™ Anti-PDGFRB Recombinant Antibody (AFC-TAB-448CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | Human IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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