Recombinant Humanized Anti-Pertussis toxin Antibody Fab Fragment (hu1B7-YTE) (CAT#: HPAB-N0229-YC-F(E))
To extend the plasma half-life of the hu1B7 antibody, three amino acid changes were introduced into the CH2 domain of the human IgGl Fc region. These changes, M252Y/S254T/T256E, referred to as YTE, function to increase the antibody's affinity for the neonatal Fc receptor, but only at the low, endosomal pH. Thus, when the antibody is taken up by this receptor, it is not released in the endosome and is recycled to the cell surface where it is released back into circulation. The YTE changes may also reduce binding to several Fey receptors, in particular FcyRIII. HulB7-YTE extended half-life antibody was generated via transient expression in CHO cells.
Specific Inquiry
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized Fab
- Specificity
- B. pertussis
- Species Reactivity
- B. pertussis
- Clone
- hu1B7-YTE
- Applications
- ELISA
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone hu1B7-YTE"
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-796-MZ | Anti-B. pertussis toxin Polyclonal Antibody | WB | Rabbit antibody |
| MOB-2487CT | Recombinant Mouse anti-Pertussis Toxin (subunit S2) Monoclonal antibody (IZC 334-02) | ELISA, WB | |
| HPAB-N0229-YC | Recombinant Humanized Anti-Pertussis toxin Antibody (hu1B7-YTE) | ELISA | Humanized IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0229-YC-S(P) | Recombinant Humanized Anti-Pertussis toxin Antibody scFv Fragment (hu1B7-YTE) | ELISA | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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