To extend the plasma half-life of the hu1B7 antibody, three amino acid changes were introduced into the CH2 domain of the human IgGl Fc region. These changes, M252Y/S254T/T256E, referred to as YTE, function to increase the antibody's affinity for the neonatal Fc receptor, but only at the low, endosomal pH. Thus, when the antibody is taken up by this receptor, it is not released in the endosome and is recycled to the cell surface where it is released back into circulation. The YTE changes may also reduce binding to several Fey receptors, in particular FcyRIII. HulB7-YTE extended half-life antibody was generated via transient expression in CHO cells.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MRO-796-MZ | Anti-B. pertussis toxin Polyclonal Antibody | WB | Rabbit antibody |
MOB-2487CT | Recombinant Mouse anti-Pertussis Toxin (subunit S2) Monoclonal antibody (IZC 334-02) | ELISA, WB | |
HPAB-N0229-YC | Recombinant Humanized Anti-Pertussis toxin Antibody (hu1B7-YTE) | ELISA | Humanized IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-N0229-YC-F(E) | Recombinant Humanized Anti-Pertussis toxin Antibody Fab Fragment (hu1B7-YTE) | ELISA | Humanized Fab |
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