Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
  • Home
  • RTN4
  • Afuco™ Anti-RTN4 ADCC Recombinant Antibody (Ozanezumab), ADCC Enhanced

Afuco™ Anti-RTN4 ADCC Recombinant Antibody (Ozanezumab), ADCC Enhanced (CAT#: AFC-TAB-903)

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human Nogo-A. Ozanezumab is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis. Ozanezumab targets a protein called Neurite Outgrowth Inhibitor (NOGO-A) or Reticulon 4. NOGO-A is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. NOGO-A is found at higher than normal levels in persons with MND.


See more Engineered Antibody products for RTN4
Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in seminiferous ducts cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6_selected.jpg
Figure 3 IHC staining of human testis
Figure 3 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_A_6_6_selected.jpg
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_B_8_5.jpg
Figure 5 Cerebellum
Figure 5 Cerebellum
(Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5388/13996_B_7_8.jpg
Figure 6 Colon
Figure 6 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_9_3.jpg
Figure 7 Testis
Figure 7 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23977/54863_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HHSteC)
Figure 8 RNA cell line category: Cell line enhanced (HHSteC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115310-RTN4

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Humanized (from mouse)
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Clone
  • Ozanezumab
  • Applications
  • IF, IP, Neut, FuncS, ELISA, FC
  • Conjugate
  • Unconjugated
  • Generic Name
  • Ozanezumab
  • Related Disease
  • Multiple sclerosis (MS)

Product Property

  • Purity
  • >95% by SDS-PAGE
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Ozanezumab; 1310680-64-8; RTN4; reticulon 4; reticulon-4; ASY; KIAA0886; NOGO; NSP CL; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; NSP; NOGOC;

Related Resources

  • Biosimilar Overview
Please refer to Ozanezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ozanezumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Ozanezumab"

Anti-Human Nogo-A Recombinant Antibody (Ozanezumab)
Recombinant humanized (from mouse) antibody expressed in CHO binding to human Nogo-A. Ozanezumab is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis. Ozanezumab targets a protein called Neurite Outgrowth Inhibitor (NOGO-A) or Reticulon 4. NOGO-A is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. NOGO-A is found at higher than normal levels in persons with MND.

See other products for "RTN4"

Recombinant Antibody

CAT Product Name Application Type
MOB-2437z Mouse Anti-RTN4 Recombinant Antibody (clone 28B12) WB, ELISA, IF, IP Mouse IgM, κ
MOB-186CQ Mouse Anti-RTN4 Antibody ELISA, WB Mouse IgG1
HPAB-0294CQ Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6) ELISA, WB Mouse IgG1
HPAB-0295CQ Human Anti-RTN4 Recombinant Antibody (clone h3A6) ELISA, WB Human IgG4
HPAB-0901-FY Human Anti-RTN4 Recombinant Antibody (HPAB-0901-FY) ELISA, Neut Humanized IgG

Human Antibody

CAT Product Name Application Type
TAB-242 Anti-Human RTN-4 Recombinant Antibody (Atinumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG4 - kappa

Mouse Antibody

CAT Product Name Application Type
TAB-531MZ Anti-Human RTN4 Recombinant Antibody (11C7) ELISA, ICC
TAB-532MZ Mouse Anti-RTN4 Recombinant Antibody (TAB-532MZ) ELISA, FC Mouse IgG
TAB-531MZ-S(P) Anti-Human RTN4 Recombinant Antibody scFv Fragment (11C7) ELISA, ICC
TAB-531MZ-F(E) Anti-Human RTN4 Recombinant Antibody Fab Fragment (11C7) ELISA, ICC
TAB-532MZ-F(E) Mouse Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-532MZ-F(E)) ELISA, FC Mouse Fab

Chimeric Antibody

CAT Product Name Application Type
TAB-533MZ Human Anti-RTN4 Recombinant Antibody (TAB-533MZ) ELISA, FC Chimeric (mouse/human) IgG
TAB-533MZ-S(P) Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-533MZ-S(P)) ELISA, FC Mouse scFv
TAB-533MZ-F(E) Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-533MZ-F(E)) ELISA, FC Chimeric (mouse/human) Fab

Humanized Antibody

CAT Product Name Application Type
TAB-534MZ Human Anti-RTN4 Recombinant Antibody (TAB-534MZ) ELISA, FC Humanized IgG
TAB-535MZ Human Anti-RTN4 Recombinant Antibody (TAB-535MZ) ELISA, FC Humanized IgG
TAB-536MZ Human Anti-RTN4 Recombinant Antibody (TAB-536MZ) ELISA, FC Humanized IgG
TAB-537MZ Human Anti-RTN4 Recombinant Antibody (TAB-537MZ) ELISA, FC Humanized IgG
TAB-534MZ-F(E) Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-534MZ-F(E)) ELISA, FC Humanized Fab

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3139 Hi-Affi™ Recombinant Rabbit Anti-RTN4 Monoclonal Antibody (DS3139AB) WB, FC IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0294CQ-F(E) Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); Fab Fragment ELISA, WB Mouse Fab
HPAB-0295CQ-F(E) Human Anti-RTN4 Recombinant Antibody (clone h3A6); Fab Fragment ELISA, WB Human Fab
HPAB-0047-WJ-F(E) Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); Fab Fragment ELISA, WB Mouse Fab
HPAB-0901-FY-S(P) Human Anti-RTN4 Recombinant Antibody; scFv Fragment (HPAB-0901-FY-S(P)) ELISA, Neut Humanized scFv

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0294CQ-S(P) Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); scFv Fragment ELISA, WB Mouse scFv
HPAB-0295CQ-S(P) Human Anti-RTN4 Recombinant Antibody (clone h3A6); scFv Fragment ELISA, WB Human scFv
HPAB-0047-WJ-S(P) Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); scFv Fragment ELISA, WB Mouse scFv
HPAB-0901-FY-F(E) Human Anti-RTN4 Recombinant Antibody; Fab Fragment (HPAB-0901-FY-F(E)) ELISA, Neut Humanized Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-242 Afuco™ Anti-RTN4 ADCC Recombinant Antibody (Atinumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for AFC-TAB-903. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart
    Inquiry

    Go to compare