Rabbit Anti-SERPINE1 Recombinant Antibody (clone R09-9D4) (CAT#: VS3-XY3500)
The rabbit recombinant antibody specifically recognizes SERPINE1 (Serpin family E member 1), which plays a role in alveolar type 2 cells senescence in the lung. This antibody specifically reacts with human SERPINE1. It has been tested using Western Blot, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50039/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50039/if_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows moderate cytoplasmic and secreted positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68501/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows moderate cytoplasmic and secreted positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68501/ihc_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50039/850_C6_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50039/850_C6_1_blue_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (BJ, HUVEC TERT2, LHCN-M2, TIME, U-138 MG, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106366-SERPINE1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106366-SERPINE1
Figure 4 RNA cell line category: Cell line enhanced (BJ, HUVEC TERT2, LHCN-M2, TIME, U-138 MG, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106366-SERPINE1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106366-SERPINE1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SERPINE1
- Species Reactivity
- Human
- Clone
- R09-9D4
- Applications
- WB, ICC, IF, IP, FC
- Related Disease
- Plasminogen Activator Inhibitor-1 Deficiency; Congenital Plasminogen Activator Inhibitor Type 1 Deficiency
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- PAI; PAI1; PAI-1; PLANH1
- Gene ID
- 5054
- UniProt ID
- P05121
- Long Name
- Serpin family E member 1
- Cellular Localization
- Secreted
- Post Translation Modifications
- Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg- -Met-370 bond. (P05121-PAI1_HUMAN)
Glycosylation at Asn232, Asn288, and Asn352 (NX_P05121 [NX_P05121-1])
Modification sites at PhosphoSitePlus (P05121)
Glycosylation from GlyConnect PAI1_HUMAN (639)
Glycosylation from GlyGen (P05121) 6 sites, 8 N-linked glycans (1 site), 2 O-linked glycans (3 sites)
- Protein Refseq
- NP_001373385.1
- Function
- Serine protease inhibitor.
Inhibits TMPRSS7 (PubMed:15853774).
Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).
As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, 9207454, 17912461).
As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705).
Acts as a regulator of cell migration, independently of its role as protease inhibitor.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SERPINE1"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1148 | Recombinant Human Anti-Human SERPINE1 Antibody scFv Fragment, clone 1040-1F6 | ELISA, WB, ICH, IP | scFv |
| DrMAB-1151 | Recombinant Human Anti-Human SERPINE1 Antibody scFv Fragment, clone 1040-1F6 [HRP] | ELISA, WB, ICH, IP | scFv |
| HPAB-0269-FY-S(P) | Human Anti-SERPINE1 Recombinant Antibody (clone PICK167-A01-fgl); scFv Fragment | FuncS, Inhib | Human scFv |
| HPAB-AP787-YC-S(P) | Human Anti-SERPINE1 Recombinant Antibody (clone CT240); scFv Fragment | ELISA, Neut | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0924CL | Mouse Anti-SERPINE1 Recombinant Antibody (TAB-0924CL) | ELISA | Mouse IgG1 |
| TAB-0924CL-S(P) | Mouse Anti-SERPINE1 Recombinant Antibody; scFv Fragment (TAB-0924CL-S(P)) | ELISA | Mouse scFv |
| TAB-0924CL-F(E) | Mouse Anti-SERPINE1 Recombinant Antibody; Fab Fragment (TAB-0924CL-F(E)) | ELISA | Mouse Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0925CL | Human Anti-SERPINE1 Recombinant Antibody (TAB-0925CL) | ELISA | Humanized IgG |
| TAB-0925CL-S(P) | Human Anti-SERPINE1 Recombinant Antibody; scFv Fragment (TAB-0925CL-S(P)) | ELISA | Humanized scFv |
| TAB-0926CL-S(P) | Anti-Human SERPINE1 Recombinant Antibody scFv Fragment (CT110) | Immunohistochemical staining, WB, ELISA | Humanized antibody |
| TAB-0927CL-S(P) | Anti-Human SERPINE1 Recombinant Antibody scFv Fragment (CT140) | Immunohistochemical staining, WB, ELISA | Humanized antibody |
| TAB-0928CL-S(P) | Anti-Human SERPINE1 Recombinant Antibody scFv Fragment (55F4C12) | Immunohistochemical staining, WB, ELISA | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0929CL | Human Anti-SERPINE1 Recombinant Antibody (TAB-0929CL) | ELISA | Human antibody |
| TAB-0923CL-S(P) | Human Anti-SERPINE1 Recombinant Antibody; scFv Fragment (TAB-0923CL-S(P)) | ELISA | Human scFv |
| TAB-0929CL-S(P) | Human Anti-SERPINE1 Recombinant Antibody; scFv Fragment (TAB-0929CL-S(P)) | ELISA | Human scFv |
| TAB-0923CL-F(E) | Human Anti-SERPINE1 Recombinant Antibody; Fab Fragment (TAB-0923CL-F(E)) | ELISA | Human Fab |
| TAB-0929CL-F(E) | Human Anti-SERPINE1 Recombinant Antibody; Fab Fragment (TAB-0929CL-F(E)) | ELISA | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1525CT | Recombinant Mouse anti-Human SERPINE1 Monoclonal antibody (4B230) | WB | |
| HPAB-0269-FY | Human Anti-SERPINE1 Recombinant Antibody (clone PICK167-A01-fgl) | FuncS, Inhib | Human IgG1, κ |
| ZG-0077U | Rabbit Anti-SERPINE1 Recombinant Antibody (clone 10C3) | ELISA, WB, IHC | Rabbit IgG |
| VS3-QX1004 | Mouse Anti-SERPINE1 Recombinant Antibody (clone 1D5) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-WK183 | Mouse Anti-SERPINE1 Recombinant Antibody (clone H9-D5) | WB, ELISA | Mouse IgG1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1944CQ | Recombinant Mouse Anti-SERPINE1 Antibody (124K1) | ELISA, Neut, WB | IgG1, κ |
| NEUT-1945CQ | Recombinant Mouse Anti-SERPINE1 Antibody (12V3) | Neut, WB | IgG1 |
| NEUT-1946CQ | Recombinant Mouse Anti-SERPINE1 Antibody (33B8) | ELISA, Neut, WB | IgG1, κ |
| NEUT-1947CQ | Recombinant Mouse Anti-SERPINE1 Antibody (33H1F7) | ELISA, IHC-P, Neut, WB | IgG1 |
| NEUT-1948CQ | Recombinant Mouse Anti-SERPINE1 Antibody (CBL946) | ELISA, IHC, Neut, WB | IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3223 | Hi-Affi™ Recombinant Rabbit Anti-SERPINE1 Monoclonal Antibody (DS3223AB) | WB, IP | IgG |
| MOR-4719 | Hi-Affi™ Recombinant Rabbit Anti-SERPINE1 Monoclonal Antibody (TH233DS) | WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0269-FY-F(E) | Human Anti-SERPINE1 Recombinant Antibody (clone PICK167-A01-fgl); Fab Fragment | FuncS, Inhib | Human Fab, κ |
| HPAB-AP787-YC-F(E) | Human Anti-SERPINE1 Recombinant Antibody (clone CT240); Fab Fragment | ELISA, Neut | Humanized Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABJ-0054 | Camelid Anti-SERPINE1 Recombinant Antibody (PABJ-0054) | ELISA, Inhib | Camelid VHH |
| PABJ-0055 | Camelid Anti-SERPINE1 Recombinant Antibody (PABJ-0055) | ELISA, Inhib | Camelid VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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