Human Anti-TROVE2 Recombinant Antibody (clone P1M398) (CAT#: FAMAB-0163JF)
Recombinant monoclonal antibody specially binds to TROVE domain family member 2 (TROVE2). This rabbit anti-TROVE2 antibody (P1M398) can be useful in the treatment of SLE patients.
Specific Inquiry
FC
Figure 1 Flow cytometric analysis of the surface Toll-like receptor (TLR)expression by untreated or polyI:C-treated Hela cells revealed significant constitutive expression of these receptors in both SGEC and HeLa cells, which is not affected significantly by TLR-3 stimulation.
Mean fold increase of mRNA expression following polyI:C (PIC) or lipopolysaccharide (LPS) treatment of salivary gland epithelial cells (SGECs) or HeLa cells.
Kyriakidis, N. C., Kapsogeorgou, E. K., Gourzi, V. C., Konsta, O. D., Baltatzis, G. E., & Tzioufas, A. G. (2014). T oll‐like receptor 3 stimulation promotes Ro 52/TRIM 21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway. Clinical & Experimental Immunology, 178(3), 548-560.
FuncS
Figure 2 Ro60/TROVE2 expression in HeLa cells was not affected by polyI:C (thin continuous line) or LPS (dotted line) treatment.
Standard errors are representative of all 22 SGEC lines and three different experiments on HeLa cells, whereas statistical significance is indicated by asterisks.
Kyriakidis, N. C., Kapsogeorgou, E. K., Gourzi, V. C., Konsta, O. D., Baltatzis, G. E., & Tzioufas, A. G. (2014). T oll‐like receptor 3 stimulation promotes Ro 52/TRIM 21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway. Clinical & Experimental Immunology, 178(3), 548-560.
WB
Figure 3 Immunoblotting analysis did not reveal any notable changes in protein expression levels of Ro60/TROVE2 in lipopolysaccharide (LPS) treatment.
β-actin and histone-H4 were used as loading controls for cytoplasmic and nuclear extracts, respectively.
Kyriakidis, N. C., Kapsogeorgou, E. K., Gourzi, V. C., Konsta, O. D., Baltatzis, G. E., & Tzioufas, A. G. (2014). T oll‐like receptor 3 stimulation promotes Ro 52/TRIM 21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway. Clinical & Experimental Immunology, 178(3), 548-560.
IF
Figure 4 LPS treatment had no effect on Ro60/TROVE2 protein expression or distribution.
A representative example of SGEC lines.
Kyriakidis, N. C., Kapsogeorgou, E. K., Gourzi, V. C., Konsta, O. D., Baltatzis, G. E., & Tzioufas, A. G. (2014). T oll‐like receptor 3 stimulation promotes Ro 52/TRIM 21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway. Clinical & Experimental Immunology, 178(3), 548-560.
Specifications
- Host Species
- Human
- Type
- Human IgM, λ
- Specificity
- Human TROVE2
- Species Reactivity
- Human
- Clone
- P1M398
- Applications
- WB, IF, FC, FuncS
- Related Disease
- Systemic lupus erythematosus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The TROVE2 antibody has been reported in applications of Western Blot, Flow Cytometry, Functional Assay, Immunofluorescence.
Target
- Alternative Names
- TROVE2; 60 KDa Ribonucleoprotein Ro; SSA2; RO60; Sjogren Syndrome Antigen A2 (60kDa, Ribonucleoprotein Autoantigen SS-A/Ro); Ro 60 KDa Autoantigen; SS-A; 60 KDa Ro Protein
- Gene ID
- 6738
- UniProt ID
- P10155
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1247z | Mouse Anti-TROVE2 Recombinant Antibody (clone 21C2) | ELISA, IHC, WB | Mouse IgG2a, κ |
| MOB-2110CT | Recombinant Mouse anti-Human TROVE2 Monoclonal antibody (EML2099) | WB | |
| FAMAB-0164JF | Human Anti-TROVE2 Recombinant Antibody (clone P1M49) | WB, ELISA, IHC, FC | Human IgM, λ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0163JF-F(E) | Human Anti-TROVE2 Recombinant Antibody (clone P1M398); Fab Fragment | IF, ELISA, FuncS | Human Fab |
| FAMAB-0164JF-F(E) | Human Anti-TROVE2 Recombinant Antibody (clone P1M49); Fab Fragment | IF, ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0163JF-S(P) | Human Anti-TROVE2 Recombinant Antibody (clone P1M398); scFv Fragment | IF, ELISA, FuncS | Human scFv |
| FAMAB-0164JF-S(P) | Human Anti-TROVE2 Recombinant Antibody (clone P1M49); scFv Fragment | IF, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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