This product is a recombinant antibody that recognizes VEGFA. The monoclonal antibody AB014 reacts with the epitope of VEGFA.
Figure 1 ABT-165 DVD-Ig inhibits the function of DLL4 and VEGF.
VEGF potentiates the activity of ABT-165. The activities of ABT-165 and the combination of DLL4 and VEGF mAb mixture were analyzed in the Notch activation bioassay in the presence or absence of recombinant VEGF (6 nmol/L). A nonrelevant recombinant protein, BSG2, was used as the negative control.
Li, Y., Hickson, J. A., Ambrosi, D. J., Haasch, D. L., Foster-Duke, K. D., Eaton, L. J., ... & Zhang, C. (2018). ABT-165, a dual variable domain immunoglobulin (DVD-Ig) targeting DLL4 and VEGF, demonstrates superior efficacy and favorable safety profiles in preclinical models. Molecular cancer therapeutics, 17(5), 1039-1050.
Figure 2 ABT-165 inhibits tumor growth and decreases functional tumor angiogenesis.
U87-MG xenograft tumors were sectioned seven days postintraperitoneal administration of a single 5 mg/kg dose of mAbs or 6.7 mg/kg dose of ABT-165. Within viable regions of treated tumors, lectin perfusion (FITC, green) or anti-CD31 (PE, red) staining was performed. Colocalization for both lectin/FITC and CD31/PE labeling is depicted in orange (Merge panel). Nuclei were stained with DAPI (blue). Percent positive functional vessels (lectin staining), and vascular density quantitation (CD31 staining) are graphed below (*, P values <0.05 compared with control group).
Li, Y., Hickson, J. A., Ambrosi, D. J., Haasch, D. L., Foster-Duke, K. D., Eaton, L. J., ... & Zhang, C. (2018). ABT-165, a dual variable domain immunoglobulin (DVD-Ig) targeting DLL4 and VEGF, demonstrates superior efficacy and favorable safety profiles in preclinical models. Molecular cancer therapeutics, 17(5), 1039-1050.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H73 | Anti-Human VEGFA Recombinant Antibody (Vanucizumab) | WB, FC, IP, ELISA, Neut, FuncS, IF | VH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappa |
TAB-011 | Anti-Human VEGF Recombinant Antibody (Bevacizumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
TAB-012-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (Ranibizumab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | Fab - G1 - kappa |
TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L043L | anti-VEGFA immunotoxin Ng76 (scFv)-Luffin-β | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-284CQ | Human Anti-VEGFA Recombinant Antibody (TAB-284CQ) | WB | Human antibody |
TAB-284CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-284CQ-S(P)) | ELISA | Human scFv |
TAB-284CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-284CQ-F(E)) | ELISA | Human Fab |
TAB-304CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1) | ELISA, WB | Human antibody |
TAB-305CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1-32) | ELISA, WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-306CQ | Mouse Anti-VEGFA Recombinant Antibody (TAB-306CQ) | FuncS, Inhib | Mouse IgG |
TAB-306CQ-S(P) | Mouse Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-306CQ-S(P)) | ELISA, Neut | Mouse scFv |
TAB-306CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-306CQ-F(E)) | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0623MZ | Chicken Anti-VEGF Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2257CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 16F1) | WB, Neut | Mouse IgG2a |
NEUT-2258CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 4B2-8) | ELISA, Neut, WB | Mouse IgG1, κ |
NEUT-2260CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL737) | WB, ELISA, Neut | Mouse IgG2b |
NEUT-2261CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL738) | WB, IHC, ELISA, Neut | Mouse IgG2b |
NEUT-2262CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL928) | Neut | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2259CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A.4.6.1) | ELISA, IP, WB, Block, FC, IHC | Mouse IgG1, κ |
NEUT-2267CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A15136B) | WB, Block | Mouse IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3835 | Rabbit Anti-VEGFA Recombinant Antibody (clone DS3835AB) | FC, ICC, IF, IHC-P, IP, WB | Rabbit IgG |
MOR-4758 | Rabbit Anti-Vegfa Recombinant Antibody (clone TH272DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MD-ZBF-YC024 | Camelid Anti-VEGFA Recombinant Single Domain Antibody (MD-ZBF-YC024) | ELlSA | Camelid VHH |
HPAB-0646-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (HPAB-0646-YJ-VHH) | ELISA, Inhib | Camelid VHH |
HPAB-0647-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (HPAB-0647-YJ-VHH) | ELISA, Inhib | Camelid VHH |
HPAB-0648-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (HPAB-0648-YJ-VHH) | ELISA, Inhib | Camelid VHH |
NBD-0090-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (NBD-0090-YJ-VHH) | ELISA, WB, Inhib | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1578-CN | Rabbit Anti-VEGFA Recombinant Antibody (clone CBACN-578) | IF, IHC, IP, FC | Rabbit IgG |
HPAB-0243-YJ | Mouse Anti-VEGFA Recombinant Antibody (clone 16-3) | ELISA, Block | Mouse IgG1,κ |
HPAB-0244-YJ | Mouse Anti-VEGFA Recombinant Antibody (clone 16-5) | ELISA, Block | Mouse IgG2b,κ |
HPAB-M0242-YC | Human Anti-VEGFA Recombinant Antibody (clone B5E3) | ELISA | Humanized IgG |
HPAB-M0243-YC | Human Anti-VEGFA Recombinant Antibody (clone Bev-B5E3BsAb) | ELISA, Block, Inhib | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-465CQ | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Varisacumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-011 | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Bevacizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0372-YC-F(E) | Canine Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-M0372-YC-F(E)) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) Fab |
HPAB-M0373-YC-F(E) | Canine Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-M0373-YC-F(E)) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) Fab |
HPAB-M0374-YC-F(E) | Canine Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-M0374-YC-F(E)) | ELISA, Inhib, FuncS | Chimeric (Mouse/Canine) Fab |
HPAB-0006-YJ-F(E) | Human Anti-VEGFA Recombinant Antibody (clone Y0317); Fab Fragment | ELISA, FuncS, In vivo | Humanized Fab |
HPAB-0060-YJ-F(E) | Mouse Anti-VEGFA Recombinant Antibody (clone 2C3); Fab Fragment | Block, ELISA, FuncS, IP | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0938WJ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (HPAB-0938WJ-S(P)) | ELISA | Human scFv |
HPAB-J0270-YC-S(P) | Human Anti-VEGFA Recombinant Antibody (clone XPA.10.064.03); scFv Fragment | ELISA, Inhib | Human scFv |
HPAB-J0271-YC-S(P) | Human Anti-VEGFA Recombinant Antibody (clone XPA.10.064.04); scFv Fragment | ELISA, Inhib | Human scFv |
HPAB-J0272-YC-S(P) | Human Anti-VEGFA Recombinant Antibody (clone XPA.10.064.06); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
HPAB-J0273-YC-S(P) | Human Anti-VEGFA Recombinant Antibody (clone XPA.10.064.07); scFv Fragment | ELISA, Inhib | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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