The affinity matured antibodies XPA.10.064.03, XPA.10.064.04, XPA.10.064.06, XPA.10.064.07, and XPA.10.064.10 as provided herein were generated by random mutagenesis of XPA.10.064 HCDR3 and subsequent binding and functional assays. The binding affinities of the affinity matured antibodies for hVEGF165 are greater than that of Bevacizumab.
Figure 1 Inhibition of hVEGF165 binding to VEGF-R1 by Bevacizumab (BM1), XPA.10.064, and XPA.10.072.
Figure 2 Analysis of hVEGF-|65 epitopes bound by Bevacizumab (BM1), XPA.10.064 (064), and XPA.10.072 (072).
Figure 3 Inhibition of HUVEC proliferation by XPA.10.064 lgG2.
Figure 4 Inhibition of A673 tumor growth in vivo by XPA.10.064.06.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H73 | Anti-Human VEGFA Recombinant Antibody (Vanucizumab) | WB, FC, IP, ELISA, Neut, FuncS, IF | VH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappa |
TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
TAB-307CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-307CQ-F(E)) | ELISA, Neut | Humanized Fab |
TAB-009ML | Anti-Human VEGFA Recombinant Antibody scFv Fragment (Brolucizumab) | ELISA, IHC, FC, IP, IF, Inhib | scFv, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L043L | anti-VEGFA immunotoxin Ng76 (scFv)-Luffin-β | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-358 | Human Anti-VEGFA Recombinant Antibody (clone 5A12); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBZ-131 | Human Anti-VEGFA Recombinant Antibody (clone bH1); scFv Fragment | WB, IF, FuncS | Human scFv |
PSBW-131 | Human Anti-VEGFA Recombinant Antibody (clone YC159); scFv Fragment | WB, ELISA | Human scFv |
HPAB-0922-WJ-S(P) | Mouse Anti-VEGFA Recombinant Antibody; scFv Fragment (HPAB-0922-WJ-S(P)) | ELISA | Mouse scFv |
HPAB-2046-FY-S(P) | Human Anti-VEGFA Recombinant Antibody (clone C1039); scFv Fragment | IA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-358 | Human Anti-VEGFA Recombinant Antibody (clone 5A12); Fab Fragment | WB, ELISA, FuncS | Human Fab |
PFBZ-131 | Human Anti-VEGFA Recombinant Antibody (clone bH1); Fab Fragment | WB, IF, FuncS | Human Fab |
PFBW-131 | Human Anti-VEGFA Recombinant Antibody (clone YC159); Fab Fragment | WB, ELISA | Human Fab |
HPAB-0151-FY-F(E) | Human Anti-VEGFA Recombinant Antibody (clone rhVVH); Fab Fragment | WB, ELISA, Inhib | Human Fab |
HPAB-0330CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody (clone mAb G6-31); Fab Fragment | ELISA, IF, Block | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-284CQ | Human Anti-VEGFA Recombinant Antibody (TAB-284CQ) | WB | Human antibody |
TAB-304CQ | Anti-Human VEGFA Recombinant Antibody (2H1) | ELISA | Human antibody |
TAB-284CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-284CQ-F(E)) | ELISA | Human Fab |
TAB-304CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1) | ELISA, WB | Human antibody |
TAB-305CQ-F(E) | Anti-Human VEGFA Recombinant Antibody Fab Fragment (2H1-32) | ELISA, WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-306CQ | Mouse Anti-VEGFA Recombinant Antibody (TAB-306CQ) | FuncS, Inhib | Mouse IgG |
TAB-306CQ-S(P) | Mouse Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-306CQ-S(P)) | ELISA, Neut | Mouse scFv |
TAB-306CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-306CQ-F(E)) | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0623MZ | Chicken Anti-VEGF Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2257CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 16F1) | WB, Neut | Mouse IgG2a |
NEUT-2258CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 4B2-8) | ELISA, Neut, WB | Mouse IgG1, κ |
NEUT-2260CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL737) | WB, ELISA, Neut | Mouse IgG2b |
NEUT-2261CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL738) | WB, IHC, ELISA, Neut | Mouse IgG2b |
NEUT-2262CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL928) | Neut | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2259CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A.4.6.1) | ELISA, IP, WB, Block, FC, IHC | Mouse IgG1, κ |
NEUT-2267CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A15136B) | WB, Block | Mouse IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3835 | Rabbit Anti-VEGFA Recombinant Antibody (clone DS3835AB) | FC, ICC, IF, IHC-P, IP, WB | Rabbit IgG |
MOR-4758 | Rabbit Anti-Vegfa Recombinant Antibody (clone TH272DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0330CQ | Mouse Anti-VEGFA Recombinant Antibody (clone mAb G6-31) | ELISA, IF, Block, FuncS | Chimeric (mouse/human) IgG |
FN-019CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 3(6D3)) | ELISA, FuncS, WB | Mouse IgG1 |
HPAB-0348-WJ | Human Anti-VEGFA Recombinant Antibody (clone 7F2) | ELISA | Humanized IgG |
HPAB-0349-WJ | Human Anti-VEGFA Recombinant Antibody (clone 6B2) | ELISA | Humanized IgG |
HPAB-M0372-YC | Canine Anti-VEGFA Recombinant Antibody (HPAB-M0372-YC) | FuncS, Inhib | Chimeric (Mouse/Canine) IgGB, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-465CQ | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Varisacumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-011 | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Bevacizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0337-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (HPAB-0337-YJ-vNAR) | FC, ELISA, Inhib, Neut | Shark vNAR |
HPAB-0338-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (HPAB-0338-YJ-vNAR) | FC, ELISA, Inhib, Neut | Shark vNAR |
HPAB-0646-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (HPAB-0646-YJ-VHH) | ELISA, Inhib | Camelid VHH |
HPAB-0647-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (HPAB-0647-YJ-VHH) | ELISA, Inhib | Camelid VHH |
HPAB-0648-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (HPAB-0648-YJ-VHH) | ELISA, Inhib | Camelid VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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