Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins
Intracellular
Cell type enhanced (Spermatogonia, Spermatocytes, Extravillous trophoblasts, Erythroid cells, Cholangiocytes)
Immune cell enhanced (T-reg)
Low cell line specificity
Interacts (phosphorylated by ATR) with RAD51 (PubMed:15665856). Interacts with and phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1 (PubMed:16963448). Interacts with BRCA1 (PubMed:11836499). Interacts with and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:9278511). Interacts with FBXO6, which regulates CHEK1 (PubMed:19716789). Interacts with PPM1D, which regulates CHEK1 through dephosphorylation (PubMed:15870257). Interacts with TIMELESS; DNA damage-dependent (PubMed:15798197). Interacts with FEM1B; activates CHEK1 in response to stress (PubMed:19330022). Interacts with TLK1 (PubMed:12660173). Interacts with XPO1 and YWHAZ (PubMed:12676962). Interacts with CDK5RAP3; antagonizes CHEK1 (PubMed:19223857). [Isoform 1]: Isoform 1 associates with isoform 2, the interaction is disrupted upon phosphorylation by ATR.
Kinase, Serine/threonine-protein kinase, Transferase
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For Research Use Only. Not For Clinical Use.