Products

Anti-α-FR Immunocytokine, IL2-scFv (MOV19) (ACFP-SH052)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-α-FR scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the α-FR as well as the biological activity of IL2. This construct might improve the tissue penetration and distribution of the fusion protein within the tumor, reduce its immunogenicity, and avoid the toxicity related to the systemic administration of IL2. This immunocytokine was designed for treating ovarian cancer.      

Specifications
Target
α-FR
Molecule Class
IL2-scFv
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
MOV19
Related Disease
Ovarian cancer
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein
Entrez Gene ID
2348
UniProt ID
P15328

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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