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Anti-BaX Intrabody [(D-Arg)9] (IAB-B001(A))

Recombinant anti-BaX intrabody linked to (D-Arg)9 works within cells to bind pro-apoptotic protein BaX, expressed in CHO cells. These intrabodies are useful drugs on their own as well as a means for identifying small compound drugs for degenerative diseases involving oxidative-stress-induced apoptosis.      

Specifications
Immunogen
human BCL2-associated X protein
Host
llama
Type
vhh-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
human
Applications
Formats of immunological tests: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies
Target
Alternative Names
BAX; BCL2-associated X protein; BCL2L4; apoptosis regulator BAX; bcl2-L-4; Baxdelta2G9; Baxdelta2omega; Baxdelta2G9omega
Entrez Gene ID
581
UniProt ID
Q07812

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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