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Anti-HER2/neu Immunocytokine, IgG (trastuzumab)-IL2 (ACFP-SH064)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HER2/neu IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HER2/neu as well as the biological activity of IL2. The anti-HER2/neu IgG3-(IL2) fusion protein is effective in eliciting protection as a direct therapeutic agent against a tumor model expressing HER2/neu. This immunocytokine was designed for treating HER-2/neu over-expressing cancer.      

Specifications
Target
HER2/neu
Molecule Class
L Kappa; IgG1-IL2
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
trastuzumab
Related Disease
HER-2/neu over-expressing cancer
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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