Recombinant monoclonal antibody to HER2/neu. This antibody intended for the prophylaxis and treatment of HER2-positive breast cancer.
Figure 1 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
Flow cytometry shows that pretreatment of SK-OV-3 and BT-474 cells with the anti-HER2 mAb trastuzumab does not block binding of the C6.5db to cells as compared with those pretreated with the anti-CD20 mAb rituximab.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
Figure 2 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
HER2 ECD-coupled agarose beads pretreated with saturating amount of trastuzumab precipitate C6.5db to equal levels as beads pretreated with either rituximab or PBS.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
Figure 3 C6.5db does not compete with trastuzumab for binding to HER2 in vitro.
Pretreating SK-OV-3 and BT-474 cells with either pertuzumab (D) or C6.5db (E) blocks the ability of the other antibody to bind to the cells. Shaded histogram, no primary antibody. DB, C6.5db; R, rituximab; T, trastuzumab; P, pertuzumab.
Reddy, S., Shaller, C. C., Doss, M., Shchaveleva, I., Marks, J. D., Jian, Q. Y., & Robinson, M. K. (2011). Evaluation of the anti-HER2 C6. 5 diabody as a PET radiotracer to monitor HER2 status and predict response to trastuzumab treatment. Clinical Cancer Research, 17(6), 1509-1520.
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CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-761 | Anti-ERBB2 Recombinant Antibody (Margetuximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
TAB-049CT | Anti-Human HER2/neu Recombinant Antibody (ChA21) | IHC, Inhib, WB, Activ, FC | Chimeric antibody (mouse/human) |
TAB-049CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
TAB-049CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G022E | Anti-ERBB2 immunotoxin 4D5 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G022D | Anti-ERBB2 immunotoxin 4D5 (scFv)-DT | Cytotoxicity assay, Function study | |
AGTO-G022G | Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel | Cytotoxicity assay, Function study | |
AGTO-G022R | Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA | Cytotoxicity assay, Function study | |
AGTO-G022S | Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PNBL-066 | Recombinant Anti-HER2 VHH Single Domain Antibody (Gr3) | SPR | Llama VHH |
PNBL-067 | Recombinant Anti-HER2 VHH Single Domain Antibody (Gr6) | SPR | Llama VHH |
TAB-032CT | Anti-Human HER2/neu Therapeutic Single Domain Antibody | WB | Single domain antibody |
TAB-046CT | Anti-Human HER2/neu Therapeutic Single Domain Antibody (Gr3) | ELISA, Inhibition, FC | Single domain antibody |
TAB-047CT | Anti-Human HER2/neu Therapeutic Single Domain Antibody (Gr6) | WB | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-054CT | Humanized Anti-Human HER2/neu Recombinant Antibody | ELISA, Inhibition, FC | Humanized antibody |
TAB-050CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (HuA21) | ELISA, WB | Humanized antibody |
TAB-053CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-053CT-S(P)) | ELISA, Inhib, FC | Humanized scFv |
TAB-054CT-S(P) | Humanized Anti-Human HER2/neu Recombinant Antibody scFv Fragment | ELISA, Inhibition, FC | Humanized antibody |
TAB-041CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-041CT-F(E)) | ELISA, WB | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-034CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (pertuzumab ) | WB | |
TAB-036CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (6B2) | ELISA, WB | |
TAB-037CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (7C2/7F3) | ELISA, WB | |
TAB-270CQ-S(P) | Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-270CQ-S(P)) | WB, Inhib | Mouse scFv |
TAB-270CQ-F(E) | Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-270CQ-F(E)) | WB, Inhib | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-045CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (Erbicin) | ELISA, Inhibition | Human antibody |
TAB-048CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-048CT-F(E)) | ELISA, WB | Human Fab |
TAB-055CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment | WB | Human antibody |
TAB-056CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-056CT-F(E)) | WB | Human Fab |
PABX-081-S (P) | Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr3) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-024LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
Gly-039LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-117LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Gly-118LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
Gly-145LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
Gly-146LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
Gly-147LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-177LC | Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0195MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
BRD-0695MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
BRD-0779MZ | Chicken Anti-ErbB2 Polyclonal IgY | ICC, IF, IHC, IP | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-737CQ | Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) | Block, IP, IF, FC | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1178 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB) | IHC-P, IHC-Fr | Rabbit IgG |
MOR-4586 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS) | WB | Rabbit IgG |
MOR-4587 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC2839 | APC-A*02:01/Human ERBB2 (VLIQRNPQL) MHC Tetramer | FCM | |
MHC-LC2840 | APC-A*02:01/Human ERBB2 (VVLGVVFGI) MHC Tetramer | FCM | |
MHC-LC2841 | APC-A*02:01/Human ERBB2 (YMIMVKCWMI) MHC Tetramer | FCM | |
MHC-YF221 | A*02:01/Human Her-2/neu (KIFGSLAFL) MHC Monomer | MHC Multimer | |
MHC-YF222 | A*02:01/Human Her-2/neu (RLLQETELV) MHC Monomer | MHC Multimer |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0010-FY | Human Anti-ERBB2 Recombinant Antibody (HPAB-0010-FY) | ELISA, FC, ADCC | Human IgG1, κ |
HPAB-0011-FY | Mouse Anti-ERBB2 Recombinant Antibody (HPAB-0011-FY) | Inhib, ADCC, FuncS | Mouse IgG1, κ |
HPAB-0733LY | Human Anti-ERBB2 Recombinant Antibody (clone AH06) | ELISA | Human IgG |
HPAB-0734LY | Human Anti-ERBB2 Recombinant Antibody (clone A058) | ELISA | Human IgG |
HPAB-0735LY | Human Anti-ERBB2 Recombinant Antibody (clone AH16) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0010-FY-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0010-FY-F(E)) | ELISA, FC | Human Fab |
HPAB-0011-FY-F(E) | Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0011-FY-F(E)) | Inhib | Mouse Fab |
HPAB-0733LY-F(E) | Human Anti-ERBB2 Recombinant Antibody (clone AH06); Fab Fragment | ELISA | Human Fab |
HPAB-0734LY-F(E) | Human Anti-ERBB2 Recombinant Antibody (clone A058); Fab Fragment | ELISA | Human Fab |
HPAB-0735LY-F(E) | Human Anti-ERBB2 Recombinant Antibody (clone AH16); Fab Fragment | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-468CQ | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Timigutuzumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-053 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Pertuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-761 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Margetuximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-005 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Trastuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1333WJ-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone 3.F2); scFv Fragment | ELISA, WB | Human scFv |
HPAB-1334WJ-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone 1.D2); scFv Fragment | ELISA, WB | Human scFv |
HPAB-1335WJ-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone 2.E8); scFv Fragment | ELISA, WB | Human scFv |
HPAB-0679YY-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone H2-18); scFv Fragment | ELISA | Human scFv |
PSBS-0070 | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (PSBS-0070) | ELISA, FuncS | Human scFv |
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