Recombinant shark antibody specifically binds to Plasmodium falciparum AMA1, expressed in Chinese Hamster Ovary cells(CHO).
Figure 1 Affinity maturation of V(NAR) 12Y-2 by error-prone PCR.
BIAcore sensorgrams comparing the binding of identical concentrations of the parental and mutant proteins to immobilized AMA1 at a constant flow rate of 5 ul/min with an injection volume of 35 ul.
Nuttall, S. D., Humberstone, K. S., Krishnan, U. V., Carmichael, J. A., Doughty, L., Hattarki, M., ... & Irving, R. A. (2004). Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1. PROTEINS: Structure, Function, and Bioinformatics, 55(1), 187-197.
Figure 2 Parasite Invasion Inhibition
Recombinant V(NAR) domains inhibit invasion of erythrocytes by P. falciparum 3D7 parasites. Data are represented as the mean ± standard error of quadruplicate experiments.
Henderson, K. A., Streltsov, V. A., Coley, A. M., Dolezal, O., Hudson, P. J., Batchelor, A. H., ... & Foley, M. (2007). Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition. Structure, 15(11), 1452-1466.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-293 | Recombinant Rat Anti-P. Knowlesi AMA-1 Antibody scFv Fragment (R31C2 ) | WB, BL, FuncS | scFv |
PFBZ-148 | Recombinant Mouse Anti-P. vivax AMA1 Antibody Fab Fragment (F8.12.19) | WB | Fab |
PSBW-097 | Recombinant Mouse Anti-P. falciparum AMA1 Antibody scFv Fragment (1F9) | ELISA, BL | scFv |
PSBZ-098 | Recombinant Mouse Anti-P. vivax AMA-1 Antibody scFv Fragment (F8.12.19) | IF | scFv |
PSBL-396 | Human Anti-AMA1 Recombinant Antibody; scFv Fragment (PSBL-396) | WB, ELISA, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-293 | Recombinant Rat Anti-P. Knowlesi AMA-1 Antibody Fab Fragment (R31C2 ) | WB, BL, FuncS | Fab |
PFBW-097 | Recombinant Mouse Anti-P. falciparum AMA1 Antibody Fab Fragment (1F9) | ELISA, BL | IgG |
PFBZ-098 | Recombinant Mouse Anti-P. vivax AMA-1 Antibody Fab Fragment (F8.12.19) | IF | IgG |
PFBL-396 | Human Anti-AMA1 Recombinant Antibody; Fab Fragment (PFBL-396) | WB, ELISA, FuncS | Human Fab |
PSBZ-148 | Recombinant Mouse Anti-P. vivax AMA1 Antibody scFv Fragment (F8.12.19) | WB | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABW-097 | Recombinant Mouse Anti-P. falciparum AMA1 Antibody (1F9) | ELISA, BL | IgG |
PABZ-098 | Recombinant Mouse Anti-P. vivax AMA-1 Antibody (F8.12.19) | IF | IgG |
PABZ-148 | Recombinant Mouse Anti-P. vivax AMA1 Antibody (F8.12.19) | WB | IgG |
MOB-2442CT | Recombinant Mouse anti-Caenorhabditis ama-1 Monoclonal antibody (3H22) | ICC/IF, ChIP, ChIP/Chip, WB, ELISA, IP, CHIPseq | |
MOB-025CQ | Rabbit Anti-P. falciparum AMA1 Antibody | ELISA, WB | Rabbit IgG |
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