Anti-TF antibody is a Human of scFv class that binds to an TF.
Figure 1 Binding of anti-TF antibodies to 6A6 antibody coated on the ELISA plate.
All antibodies analyzedwere antibody Fabs except the Herceptinw antibody, which is a full-length human antibody specific for the HER2 receptor. D3Ch is a chimeric antibody consisting of the D3H44 constant domains and murine D3 variable domains. D3H13 and D3H18 are variants of the D3H44 antibody.19 The two chimeric antibodies huVLmuVH and muVLhuVH are composed of the same D3H44 constant domains, but they combine a human and a murine variable domain. The Herceptinw antibody is identical with D3H44 except in the antigen combining region.
Eigenbrot, C., Meng, Y. G., Krishnamurthy, R., Lipari, M. T., Presta, L., Devaux, B., ... & Kirchhofer, D. (2003). Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation. Journal of molecular biology, 331(2), 433-446.
Figure 2 Neutralization of D3H44 by 6A6.
Figure 2. Neutralization of D3H44 by 6A6 in TF/F.VIIa-mediated activation of F.X. 10 nM D3H44 (F(ab')2,Fab or IgG4b) was incubated with mTF1 – 263, F.VIIa(0.02 nM) and increasing concentrations of 6A6 antibodyfor 25 minutes in HBSA buffer. F.X (200 nM) was added and at various time-points reaction aliquots were withdrawn and analyzed for F.Xa in a second stage chromogenic substrate assay. The linear rates of initial of F.Xa formation were determined and are expressed as fractional activities (vi=vo): Open circles, D3H44-F(ab')2; triangles, D3H44-IgG4b; filled circles, D3H44-Fab; squares, 5G6 antibody.
Eigenbrot, C., Meng, Y. G., Krishnamurthy, R., Lipari, M. T., Presta, L., Devaux, B., ... & Kirchhofer, D. (2003). Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation. Journal of molecular biology, 331(2), 433-446.
Figure 3 Open book views of the solvent-accessible surfaces buried in the (a) 6A6-Fab/D3H44-Fab and (b) TF/D3H44-Fab complexes.
Open book views of the solvent-accessible surfaces buried in the (a) 6A6-Fab/D3H44-Fab and (b) TF/D3H44-Fab complexes. The contact zones are colored by electrostatic potential (blue positive, red negative).
Eigenbrot, C., Meng, Y. G., Krishnamurthy, R., Lipari, M. T., Presta, L., Devaux, B., ... & Kirchhofer, D. (2003). Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation. Journal of molecular biology, 331(2), 433-446.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1092z | Mouse Anti-F3 Recombinant Antibody (clone 18C8) | WB, FC, ICC, FuncS | Mouse IgG1 |
PABZ-043 | Mouse Anti-F3 Recombinant Antibody (clone 5G9) | Block | Mouse IgG |
PABW-043 | Human Anti-F3 Recombinant Antibody (clone D3H44) | WB, IHC, IF, FuncS | Humanized IgG |
MOB-2336MZ | Recombinant Mouse Anti-Human F3 Antibody (clone 3L2) | ELISA, ICC/IF, IHC-Fr, IHC-P, IHC-P, WB | Mouse antibody |
FN-224CQ | Mouse Anti-F3 Recombinant Antibody (clone HTF-1) | FC, FuncS, ICC, IF, WB | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-258CL | Human Anti-F3 Recombinant Antibody (TAB-258CL) | ELISA | Human IgG |
TAB-276CQ-S(P) | Human Anti-F3 Recombinant Antibody; scFv Fragment (TAB-276CQ-S(P)) | ELISA, FC | Humanized scFv |
TAB-276CQ-F(E) | Human Anti-F3 Recombinant Antibody; Fab Fragment (TAB-276CQ-F(E)) | ELISA, FC | Humanized Fab |
TAB-278CQ-F(E) | Human Anti-F3 Recombinant Antibody; Fab Fragment (TAB-278CQ-F(E)) | ELISA, FC | Humanized Fab |
PABX-180-F (E) | Recombinant Human Anti-TF Antibody Fab Fragment (D3H44) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBZ-043 | Mouse Anti-F3 Recombinant Antibody (clone 5G9); Fab Fragment | Block | Mouse Fab |
PFBW-043 | Human Anti-F3 Recombinant Antibody (clone D3H44); Fab Fragment | WB, IHC, IF, FuncS | Humanized Fab |
HPAB-0172CQ-F(E) | Human Anti-F3 Recombinant Antibody; Fab Fragment (HPAB-0172CQ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
HPAB-0173CQ-F(E) | Human Anti-F3 Recombinant Antibody; Fab Fragment (HPAB-0173CQ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
HPAB-1000WJ-F(E) | Human Anti-F3 Recombinant Antibody (clone JT C5); Fab Fragment | ELISA, Inhib | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-043 | Mouse Anti-F3 Recombinant Antibody (clone 5G9); scFv Fragment | Block | Mouse scFv |
PSBW-043 | Human Anti-F3 Recombinant Antibody (clone D3H44); scFv Fragment | WB, IHC, IF, FuncS | Humanized scFv |
PSBL-468 | Human Anti-F3 Recombinant Antibody (clone 10H10); scFv Fragment | WB, IF, FuncS | Human scFv |
HPAB-0175CQ-S(P) | Human Anti-F3 Recombinant Antibody; scFv Fragment (HPAB-0175CQ-S(P)) | ELISA, WB, Inhib | Humanized scFv |
PSBC-450 | Mouse Anti-F3 Recombinant Antibody (clone 10H10); scFv Fragment | ELISA, FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-277CQ-S(P) | Mouse Anti-F3 Recombinant Antibody; scFv Fragment (TAB-277CQ-S(P)) | ELISA, FC | Mouse scFv |
TAB-277CQ-F(E) | Mouse Anti-F3 Recombinant Antibody; Fab Fragment (TAB-277CQ-F(E)) | ELISA, FC | Mouse Fab |
PABX-179 | Recombinant Mouse Anti-TF Antibody (D3) | WB, ELISA, IF, FuncS | IgG |
PABX-179-S (P) | Recombinant Mouse Anti-TF Antibody scFv Fragment (D3) | WB, ELISA, IF, FuncS | scFv |
PABX-179-F (E) | Recombinant Mouse Anti-TF Antibody Fab Fragment (D3) | WB, ELISA, IF, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-178LC | Recombinant Anti-Human F3 Antibody (Non-glycosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1226 | Hi-Affi™ Rabbit Anti-F3 Recombinant Antibody (clone DS1226AB) | WB, IHC-P, ICC, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-473CQ | Anti-Human F3 Recombinant Antibody (Tisotumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0573CQ | Mouse Anti-F3 Recombinant Antibody (clone hATR-5) | ELISA, Inhib | Mouse IgG4 |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-473CQ | Afuco™ Anti-F3 ADCC Recombinant Antibody (Tisotumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
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