Rabbit Anti-Csf1R Recombinant Antibody (clone R06-5H8) (CAT#: VS3-FY1764)

• Immunogen
• Recombinant mouse MCSF receptor protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human Csf1R

• Species Reactivity
• Human

• Clone
• R06-5H8

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 109 kDa, while the observed molecular weight stands at 109 kDa.

• Related Disease
• Alzheimer's diseases

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Colony Stimulating Factor 1 Receptor; McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog; Proto-Oncogene C-Fms; CSF-1 Receptor; CD115 Antigen; EC 2.7.10.1; M-CSF-R; CSF-1R; FMS; Macrophage Colony Stimulating Factor I Receptor

• Gene ID
• 12978

• UniProt ID
• P09581

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-559 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-559 and Tyr-807 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-697 and Tyr-921 is important for interaction with GRB2. Phosphorylation at Tyr-721 is important for interaction with PIK3R1. Phosphorylation at Tyr-721 and Tyr-807 is important for interaction with PLCG2. Phosphorylation at Tyr-974 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation.

• Protein Refseq
• NP_001275634.1; NP_001336665.1; NP_001362249.1; NP_001362250.1; NP_005202.2

• Function
• Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody