Human Anti-NTRK2 Recombinant Antibody (clone 4A6) (CAT#: HPAB-AP761-YC)
Provided are TrkB agonist antibodies, which can be used in the treatment of peripheral neuropathies, such as Charcot-Marie-Tooth disease. The antibody can be used for immunoassay techniques such as: Function Assay as a agonist.
Specific Inquiry
FuncS
Figure 1 The relative amount of neuron survival in the presence of increasing amounts of several agonist anti-TrkB humanized antibodies using an in vitro assay.
Top graph: agonist anti-TrkB humanized antibodies C1, C2, 4A6 and 4B12. Bottom graph: various isotype forms of agonist anti-TrkB humanized antibody RN1026A (1026A). Mouse monoclonal agonist anti-TrkB antibody 38B8 and/or BDNF are used positive controls. The y-axis indicates the number of neurons, and x-axis indicates the concentration of antibody (or BDNF) in pM.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Human NTRK2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 4A6
- Applications
- FuncS
- Related Disease
- Charcot-Marie-Tooth disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
- Alternative Names
- Neurotrophic Receptor Tyrosine Kinase 2; Neurotrophic Tyrosine Kinase Receptor Type 2; Tropomyosin-Related Kinase B; EC 2.7.10.1; GP145-TrkB; Trk-B; TRKB; Neurotrophic Tyrosine Kinase, Receptor, Type 2
- Gene ID
- 4915
- UniProt ID
- Q16620
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 4A6"
See other products for "NTRK2"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-171CQ | Anti-Human NTRK2 Recombinant Antibody (18H6) | ELISA, FC | |
| TAB-172CQ | Anti-Human NTRK2 Recombinant Antibody (38B8) | ELISA, FC | |
| TAB-173CQ | Anti-Human NTRK2 Recombinant Antibody (6B72C5) | ELISA, WB, IP | |
| TAB-174CQ | Anti-Human NTRK2 Recombinant Antibody (5G5D2B5) | FuncS, WB | |
| TAB-175CQ | Anti-Human NTRK2 Recombinant Antibody (17D11) | ELISA, FC, WB |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-177CQ | Anti-Human NTRK2 Recombinant Antibody (C2) | Agonist, FuncS | Humanized antibody |
| TAB-178CQ | Anti-Human NTRK2 Recombinant Antibody (A2) | ELISA, FC | Humanized antibody |
| TAB-179CQ | Anti-Human NTRK2 Recombinant Antibody (RN1026A) | ELISA, FC | Humanized antibody |
| TAB-177CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C2) | ELISA, FC | Humanized antibody |
| TAB-178CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (A2) | ELISA, FC | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-180CQ | Anti-Human NTRK2 Recombinant Antibody (C20) | FuncS | Human antibody |
| TAB-180CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C20) | ELISA, FC, WB | Human antibody |
| TAB-180CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C20) | ELISA, FC, WB | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0842MZ | Recombinant Mouse Anti-Human NTRK2 Antibody (clone 3D12) | WB | Mouse antibody |
| HPAB-N0197-YC | Mouse Anti-NTRK2 Recombinant Antibody (HPAB-N0197-YC) | FuncS, WB | Mouse IgG |
| HPAB-N0198-YC | Mouse Anti-NTRK2 Recombinant Antibody (HPAB-N0198-YC) | FuncS | Mouse IgG |
| HPAB-N0199-YC | Mouse Anti-NTRK2 Recombinant Antibody (HPAB-N0199-YC) | FuncS | Mouse IgG |
| HPAB-N0200-YC | Human Anti-NTRK2 Recombinant Antibody (HPAB-N0200-YC) | FuncS, WB | Humanized IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2509 | Hi-Affi™ Recombinant Rabbit Anti-NTRK2 Monoclonal Antibody (DS2509AB) | WB, IHC, IP | IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-095CN | Human Anti-NTRK2 Recombinant Antibody (NS-095CN) | ELISA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-095CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (NS-095CN-S(P)) | ELISA | Human scFv |
| HPAB-0662-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0662-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0663-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0663-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0664-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0664-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0665-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0665-CN-S(P)) | ELISA, Neut | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0197-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0197-YC-F(E)) | FuncS, WB | Mouse Fab |
| HPAB-N0198-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0198-YC-F(E)) | FuncS | Mouse Fab |
| HPAB-N0199-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0199-YC-F(E)) | FuncS | Mouse Fab |
| HPAB-N0200-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0200-YC-F(E)) | FuncS, WB | Humanized Fab |
| HPAB-N0201-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0201-YC-F(E)) | FuncS | Humanized Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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