Anti-Human AQP4 Recombinant Antibody (CAT#: TAB-053CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human AQP4. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO, a study on antibody titre. Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system. In most NMO patients, autoantibodiess to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/if_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5079/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5079/if_selected.jpg
Figure 3 Cerebral cortex
(Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_B_7_5.jpg
(Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_B_7_5.jpg
Figure 4 Lung
(Alveolar cells type I
Staining: High
Intensity: Strong
Quantity: 75%-25%
Alveolar cells type II
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_A_3_4.jpg
(Alveolar cells type I
Staining: High
Intensity: Strong
Quantity: 75%-25%
Alveolar cells type II
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_A_3_4.jpg
Figure 5 Kidney
(Distal tubules
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_A_8_5.jpg
(Distal tubules
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14784/141530_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (AF22, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171885-AQP4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171885-AQP4
Figure 6 RNA cell line category: Cell line enhanced (AF22, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171885-AQP4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171885-AQP4
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Neuromyelitis optica
Product Property
- Purity
- >95% by HPLC
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "AQP4"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1110z | Mouse Anti-AQP4 Recombinant Antibody (clone 28H5) | WB, IP, IF, IHC, FC | Mouse IgG3 |
| MOB-0672MZ | Mouse Anti-AQP4 Recombinant Antibody (clone 4E3) | ELISA, IHC-Fr, IHC-P, IP, WB | Mouse IgG1 |
| ZG-0035J | Mouse Anti-AQP4 Recombinant Antibody (clone 4H1) | WB, IHC-P, IF/ICC | Mouse IgG |
| VS3-CJ1042 | Mouse Anti-AQP4 Recombinant Antibody (VS3-CJ1042) | WB, ICC, IF, IHC | Mouse IgG |
| VS3-FY92 | Recombinant Mouse Anti-AQP4 Antibody (VS3-FY92) | WB, IHC, IF | Mouse IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0977CLV | Anti-Human AQP4 Recombinant Antibody (D15107) | ELISA, FuncS, WB, IF, FC | Chimeric antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0223 | Hi-Affi™ Rabbit Anti-AQP4 Recombinant Antibody (clone DS223AB) | IHC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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