Products

Anti-CD30 Immunocytokine, scFv-Fc (HRS3)-IL2 (ACFP-SH125)

The fusion protein is composed of a CD30 binding domain (HRS3-scFv) that is linked via the human IgG hinge-CH2/CH3 domain to human IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD30 as well as the biological activity of IL2. This antibody-(IL2) fusion protein retains the specificity for the CD30 antigen and the immunostimulatory function of IL2 including the activation of T and resting NK cells. HRS3scFv-Fc-(IL2) was able to induce IFN-γ secretion in SCID mice that had received subcutaneous injections of L540, a human CD30+ non-Hodgkin's lymphoma cell line, which is important for the induction of an efficient antitumor response in vivo and the shift of a T-helper type 2 (TH2) immune response in lymphoma to a TH1 response. This immunocytokine was designed for treating Hodgkin's disease (HD) anaplastic large cell lymphoma.      

Specifications
Target
CD30
Molecule Class
scFv-Fc-IL2
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
HRS3
Related Disease
Hodgkin's disease (HD) anaplastic large cell lymphoma
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily; member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen
Entrez Gene ID
943
UniProt ID
A5D8T4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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