Products

Anti-CD30 Immunocytokine, scFv-Fc (HRS3)-IL12 (ACFP-SH124)

The fusion protein is composed of a CD30 binding domain (HRS3-scFv) that is linked via the human IgG hinge-CH2/CH3 domain to human IL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD30 as well as the biological activity of IL12. The antibody-cytokine fusion proteins enhanced the cytolysis of CD30+ tumor cells and IFN-γ secretion by NK cells, and increased the activation of resting NK cells. These results support the concept that the HRS3-scFv-Fc-(IL12) fusion protein could be valuable for the specific immunotherapy of Hodgkin's lymphoma. This immunocytokine was designed for treating Hodgkin's disease (HD) anaplastic large cell lymphoma.      

Specifications
Target
CD30
Molecule Class
scFv-Fc-IL12
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
HRS3
Related Disease
Hodgkin's disease (HD) anaplastic large cell lymphoma
Cytokines 1
IL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily; member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen
Entrez Gene ID
943
UniProt ID
A5D8T4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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