Products

Anti-EGFR Immunocytokine, IL2-IgG (mAb 425) (ACFP-SH078)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EGFR IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EGFR as well as the biological activity of IL2. An in vitro analysis revealed that the IL2-FuP supported mainly proliferation and lymphokine-activated killer cell activity, and IL2-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. This immunocytokine was designed for treating any type of solid or non-solid cancer or malignant lymphoma.      

Specifications
Target
EGFR
Molecule Class
IL2-IgG2a
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
mAb 425
Related Disease
Any type of solid or non-solid cancer or malignant lymphoma
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog); ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40
Entrez Gene ID
1956
UniProt ID
P00533

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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