Recombinant monoclonal antibody to CD4. Tregalizumab is an immunomodulator. It binds to CD4.
Figure 1 Tregalizumab is able to activate the suppressive capacity of regulatory T cells.
(A) Tregs were isolated and pre-incubated with plate-bound tregalizumab, OKT-3 mAb, or medium and transferred to a mixed lymphocyte reaction using allogeneic, CD3-depleted, irradiated PBMCs to activate the proliferation of Teffs. (B) The proliferation of allogenic stimulated Teffs with tregalizumab pretreated Tregs is shown compared with the proliferation without Tregs. (C) Tregalizumab engages the TCR signaling pathway. Incubation of Tregs with tregalizumab evokes signaling events in Tregs that mimic a signal through the T cell receptor complex without the need for direct CD3 or TCR stimulation. T cell receptor complex signaling represents a crucial event in the activation of Tregs since blockade of the corresponding signaling pathway resulted in the loss of suppressive activity of Tregs. Tregalizumab delivers a comparable signal as usually conferred by TCR binding in Tregs, resulting in activation/phosphorylation of the T cell receptor downstream signaling molecule ZAP-70 (ζ-chain-associated protein). This event leads to signals that finally trigger internalization of the tregalizumab–CD4 complex. As a consequence, CD4 expression levels on CD4+ T cells are downmodulated by tregalizumab in the physiological setting. This downmodulation causes a transient decrease of CD4 molecules on the cell surface, which is followed by a recovery of expression levels over time.
König, M., Rharbaoui, F., Aigner, S., Dälken, B., & Schüttrumpf, J. (2016). Tregalizumab–a monoclonal antibody to target regulatory T cells. Frontiers in immunology, 7, 11.
Figure 2 PK/PD of CD4 "Tregalizumab".
(A) PK/PD model was established to predict time course of CD4 downmodulation (% of baseline) after weekly dosing. (B) Mean CD4 downmodulation on CD4 T cells per dose group. CD4 modulation (±SEM) was measured by FACS analysis at weeks 0, 2, 4, 6, 8, 12, 16, and 24 just prior to the next dosing.
König, M., Rharbaoui, F., Aigner, S., Dälken, B., & Schüttrumpf, J. (2016). Tregalizumab–a monoclonal antibody to target regulatory T cells. Frontiers in immunology, 7, 11.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD4. Tregalizumab is an immunomodulator. It binds to CD4.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-164 | Anti-Human CD4 Recombinant Antibody (Priliximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
TAB-165LC-S(P) | Monkey Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-165LC-S(P)) | FC, SPR, ELISA | Monkey scFv |
TAB-170LC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-170LC-S(P)) | ELISA, SPR | Rat scFv |
TAB-167LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (cM-T412) | ELISA | Chimeric antibody (mouse/human) |
TAB-170LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) | ELISA, SPR | Chimeric antibody (rat/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G078E | Anti-CD4 immunotoxin M-T151 (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-G078R | Anti-CD4 immunotoxin M-T151 (IgG)-RTA | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-423 | Human Anti-CD4 Recombinant Antibody (clone 576); Fab Fragment | WB, ELISA, FuncS | Human Fab |
PFBL-424 | Human Anti-CD4 Recombinant Antibody (clone Hu5A8); Fab Fragment | Block, Neut | Human Fab |
FAMAB-0054-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T310); Fab Fragment | Neut | Mouse Fab |
FAMAB-0055-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T404); Fab Fragment | Neut | Mouse Fab |
FAMAB-0056-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T408); Fab Fragment | Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-173LC | Anti-Human CD4 Recombinant Antibody (IgA F425-Alg8) | ELISA, Inhib | |
TAB-174LC | Mouse Anti-CD4 Recombinant Antibody (TAB-174LC) | ELISA, FC, IHC, Neut, FuncS | Mouse IgG1 |
TAB-175LC | Anti-Human CD4 Recombinant Antibody (15A7) | ELISA, FC, IF, WB, Inhib | |
TAB-176LC | Anti-Human CD4 Recombinant Antibody (14G7) | FC, ELISA, IF, Block | |
TAB-160LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (OKT4A) | ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-168LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (TRX1) | ELISA | Humanized antibody |
TAB-171LC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-171LC-S(P)) | ELISA, SPR | Humanized scFv |
TAB-172LC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-172LC-S(P)) | ELISA | Human scFv |
TAB-161LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (gOKT4A-4) | ELISA | Humanized antibody |
TAB-168LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (TRX1) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-025LC | Recombinant Anti-Human CD4 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-351CQ | Mouse Anti-CD4 Recombinant Antibody (clone 10C12) | ELISA, WB, IF, Block | Mouse IgG1 |
NEUT-352CQ | Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) | Block, ELISA, FC, IHC-Fr, WB | Mouse IgG1, κ |
NEUT-355CQ | Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) | FC, CyTOF, Block, IHC | Mouse IgG1, κ |
NEUT-357CQ | Rat Anti-CD4 Recombinant Antibody (clone MAB0810) | Block, Depletion, Stim | Rat IgG2b |
NEUT-358CQ | Rat Anti-CD4 Recombinant Antibody (clone RM4-5) | FC, CyTOF, Depletion, Block, IHC | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-353CQ | Mouse Anti-CD4 Recombinant Antibody (clone CBL976) | FC, Neut, IF, IHC | Mouse IgG1, κ |
NEUT-354CQ | Recombinant Mouse Anti-CD4 Antibody (CT-4) | Neut, FC, IHC, IHC-Fr, IHC-P, IP | IgG1, κ |
NEUT-356CQ | Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) | Neut, FC, IHC, IHC-Fr, IP, ICC | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0560 | Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0135CQ | Human Anti-CD4 Recombinant Antibody (HPAB-0135CQ) | ELISA, Inhib, FuncS | Human IgG1, κ |
HPAB-0136CQ | Mouse Anti-CD4 Recombinant Antibody (HPAB-0136CQ) | ELISA, FuncS | Mouse IgG1, κ |
HPAB-0137CQ | Mouse Anti-CD4 Recombinant Antibody (clone RIB 5/2) | IHC, FC, FuncS | Mouse IgG2a |
MRO-1750-CN | Rabbit Anti-CD4 Polyclonal Antibody (MRO-1750-CN) | WB, IF, IHC, FC | Rabbit IgG |
MRO-1751-CN | Rabbit Anti-CD4 Polyclonal Antibody (MRO-1751-CN) | WB, IF, IHC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-039 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-164 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-260 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-171 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-107 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0957WJ-S(P) | Human Anti-CD4 Recombinant Antibody (clone 4-91); scFv Fragment | ELISA | Human scFv |
HPAB-J0044-YC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0044-YC-S(P)) | ELISA, FC, CDC | Rat scFv |
HPAB-J0045-YC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0045-YC-S(P)) | ELISA, FC, CDC | Rat scFv |
HPAB-J0046-YC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0046-YC-S(P)) | ELISA, FC, CDC | Rat scFv |
HPAB-J0047-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0047-YC-S(P)) | ELISA, FC, ADCC, CDC | Rat scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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