Rabbit Anti-IL1B Recombinant Antibody (VS3-CJ265) (CAT#: VS3-CJ265)
This product is a rabbit antibody that recognizes IL1B.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ hTERT+, HBEC3-KT, HMC-1, hTEC/SVTERT24-B, hTERT-RPE1, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125538-IL1B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125538-IL1B
Figure 1 RNA cell line category: Cell line enhanced (BJ hTERT+, HBEC3-KT, HMC-1, hTEC/SVTERT24-B, hTERT-RPE1, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125538-IL1B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125538-IL1B
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IL1B
- Species Reactivity
- Human
- Applications
- WB, ICC, IF, IHC, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- IL-1 beta; Catabolin
- Gene ID
- 3553
- UniProt ID
- P01584
- Sequence Similarities
- Belongs to the IL-1 family.
- Cellular Localization
- Cytoplasm, Lysosome, Secreted
- Post Translation Modifications
- Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
- Protein Refseq
- NP_000567.1
- Function
- Potent pro-inflammatory cytokine (PubMed:3920526, PubMed:10653850, PubMed:12794819).
Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526).
Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744).
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
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TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IL1B"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-021 | Anti-Human IL1Beta Recombinant Antibody (Canakinumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
| TAB-545LC | Human Anti-IL1B Recombinant Antibody (TAB-545LC) | ELISA, Inhib, Neut | Human IgG1 |
| TAB-550LC | Anti-human IL1B Recombinant Antibody (9.5.2) (TAB-550LC) | ELISA, Inhib, FuncS | Human antibody |
| TAB-551LC | Anti-human IL1B Recombinant Antibody (5.5.1) (TAB-551LC) | ELISA, Inhib | Human antibody |
| TAB-552LC | Anti-human IL1B Recombinant Antibody (8.18.1) (TAB-552LC) | ELISA, Inhib | Human antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-239 | Human Anti-IL1B Recombinant Antibody (clone YC129); scFv Fragment | WB, IHC, FuncS | Human scFv |
| HPAB-0916-WJ-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0916-WJ-S(P)) | ELISA | Humanized scFv |
| HPAB-1748-FY-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-1748-FY-F(E)) | WB, ELISA, Block | Human Fab |
| HPAB-1266WJ-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-1266WJ-S(P)) | ELISA, WB | Mouse scFv |
| PSBS-0021 | Human Anti-IL1B Recombinant Antibody (Clone 4AB007); scFv Fragment | ELISA, FuncS | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-230CT | Mouse Anti-IL1B Recombinant Antibody (TAB-230CT) | ELISA | Mouse IgG |
| TAB-231CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (47F11) | Inhibition | |
| TAB-234CT | Rabbit Anti-IL1B Recombinant Antibody (TAB-234CT) | FC, ELISA, Neut | Rabbit IgG |
| TAB-234CT-F(E) | Rabbit Anti-IL1B Recombinant Antibody; Fab Fragment (TAB-234CT-F(E)) | FC, ELISA, Neut | Rabbit Fab |
| TAB-235CT-F(E) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (SK48-E26) | ELISA, Neut |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-233CT | Human Anti-IL1B Recombinant Antibody (TAB-233CT) | IF | Humanized IgG |
| TAB-236CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (huSK48-E26) | ELISA, Neut | Humanized antibody |
| TAB-233CT-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-233CT-S(P)) | ELISA | Humanized scFv |
| TAB-236CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (huSK48-E26) | ELISA, Neut | Humanized antibody |
| TAB-233CT-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (TAB-233CT-F(E)) | ELISA | Humanized Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-237CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (chSK48-E26) | ELISA, Neut | Chimeric antibody (mouse/human) |
| TAB-232CT-F(E) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (ch47F11) | Inhibition | Chimeric antibody (mouse/human) |
| TAB-543LC | Anti-human IL1B Recombinant Antibody, Chimeric (TAB-543LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-543LC-S(P) | Anti-human IL1B scFv Fragment, Chimeric | ELISA | Chimeric antibody (mouse/human) |
| TAB-543LC-F(E) | Anti-human IL1B Fab Fragment, Chimeric | ELISA | Chimeric antibody (mouse/human) |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0282MZ | Chicken Anti-Interleukin-1β Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1271CQ | Recombinant Mouse Anti-IL1B Antibody (CBL665) | Neut | IgG1 |
| NEUT-1272CQ | Mouse Anti-IL1B Recombinant Antibody (clone 4M27) | IHC, Neut, WB | Mouse IgG2 |
| NEUT-1273CQ | Mouse Anti-IL1B Recombinant Antibody (clone 8516.311) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-1275CQ | Mouse Anti-IL1B Recombinant Antibody (clone 2805R) | ELISA, Neut, WB, ICC | Mouse IgG1 |
| NEUT-1276CQ | Mouse Anti-IL1B Recombinant Antibody (clone CBL697) | Neut, ELISA | Mouse IgG |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1274CQ | Mouse Anti-IL1B Recombinant Antibody (clone B-A15) | Block, FC | Mouse IgG1 |
| NEUT-1285CQ | Mouse Anti-IL1B Recombinant Antibody (clone H1b-27) | ELISA, ELISPOT, Block | Mouse IgG2b, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1798 | Rabbit Anti-IL1B Recombinant Antibody (clone DS1798AB) | WB | Rabbit IgG |
| MOR-4237 | Rabbit Anti-IL1B Recombinant Antibody (clone SI316DS) | ELISA | Rabbit IgG |
| MOR-4238 | Rabbit Anti-IL1B Recombinant Antibody (clone SI317DS) | ELISA | Rabbit IgG |
| MOR-4239 | Rabbit Anti-IL1B Recombinant Antibody (clone SI318DS) | ELISA | Rabbit IgG |
| MOR-4605 | Rabbit Anti-IL1B Recombinant Antibody (clone TH118DS) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0829-CN | Rabbit Anti-IL1B Recombinant Antibody (clone CBACN-306) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-2338LY | Human Anti-IL1B Recombinant Antibody (HPAB-2338LY) | ELISA | Human IgG |
| HPAB-0978WJ | Human Anti-IL1B Recombinant Antibody (HPAB-0978WJ) | ELISA | Human IgG |
| HPAB-1748-FY | Human Anti-IL1B Recombinant Antibody (HPAB-1748-FY) | Stim, Neut, Inhib | Human IgG |
| HPAB-1171WJ | Mouse Anti-IL1B Recombinant Antibody (clone MU007) | Inhib | Mouse IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-021 | Afuco™ Anti-IL1B ADCC Recombinant Antibody (Canakinumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-161 | Afuco™ Anti-IL1B ADCC Recombinant Antibody (Gevokizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2338LY-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-2338LY-F(E)) | ELISA | Human Fab |
| HPAB-0729-FY-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0729-FY-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-0730-FY-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0730-FY-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-0858-FY-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0858-FY-S(P)) | Neut | Humanized scFv |
| HPAB-0859-FY-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0859-FY-S(P)) | Neut | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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