Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON. It has shown that antibodies 07F01, 12B11, 17F06, 18H09 and 29B06 each inhibited MSP induced ERK phosphorylation in T47D cells, while only antibodies 07F01, 18H09 and 29B06 each blocked MSP binding to hRON SEMA+PSI in the neutralization assay. This suggests that antibodies 12B11 and 17F06 do not neutralize binding of MSP to the hRON SEMA+PSI domain, neutralize binding of MSP to RON in the context of the full RON extracellular domain, or function by a mechanism other than blocking MSP binding to RON.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-184 | Anti-Human RON Recombinant Antibody (Narnatumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
TAB-332CT-S(P) | Anti-Human RON Recombinant Antibody scFv Fragment (e01h6) | WB, ELISA, FC | Human antibody |
TAB-333CT-S(P) | Human Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-333CT-S(P)) | WB, ELISA, FC, IP | Human scFv |
TAB-332CT-F(E) | Anti-Human RON Recombinant Antibody Fab Fragment (e01h6) | WB, ELISA, FC | Human antibody |
TAB-333CT-F(E) | Human Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-333CT-F(E)) | WB, ELISA, FC, IP | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-331CT-S(P) | Anti-Human RON Recombinant Antibody scFv Fragment (11H09) | WB, ELISA, FC | |
TAB-334CT-S(P) | Mouse Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-334CT-S(P)) | WB, ELISA, FC, IP | Mouse scFv |
TAB-335CT-S(P) | Mouse Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-335CT-S(P)) | WB, ELISA, FC, IP | Mouse scFv |
TAB-334CT-F(E) | Mouse Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-334CT-F(E)) | WB, ELISA, FC, IP | Mouse Fab |
TAB-335CT-F(E) | Mouse Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-335CT-F(E)) | WB, ELISA, FC, IP | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1756CQ | Recombinant Mouse Anti-MST1R Antibody (CBL312) | BL | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1757CQ | Recombinant Mouse Anti-MST1R Antibody (MM0478-10F24) | Neut | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2309 | Hi-Affi™ Recombinant Rabbit Anti-MST1R Monoclonal Antibody (DS2309AB) | FC, ICC/IF, IHC-P, IP, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0062-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07923); scFv Fragment | IP, ELISA, FC | Human scFv |
HPAB-0063-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07924); scFv Fragment | IP, ELISA, FC | Human scFv |
HPAB-0064-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07925); scFv Fragment | IP, ELISA, FC | Human scFv |
HPAB-1589-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 4C04); scFv Fragment | WB, ELISA | Mouse scFv |
HPAB-J0189-YC-S(P) | Mouse Anti-MST1R Recombinant Antibody (clone 17F06); scFv Fragment | ELISA, Neut, FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-687-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 07F01); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
HPAB-688-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 29B06); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
HPAB-689-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 18H09); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
HPAB-690-FY-F(E) | Human Anti-MST1R Recombinant Antibody (clone Sh07F01-2); Fab Fragment | Block | Chimeric (mouse/human) Fab |
HPAB-1407-FY-S(P) | Mouse Anti-MST1R Recombinant Antibody (clone RON6); Fab Fragment | ELISA, Inhib | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-184 | Afuco™ Anti-MST1R ADCC Recombinant Antibody (Narnatumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1407-FY | Mouse Anti-MST1R Recombinant Antibody (clone RON6) | ELISA, Inhib, WB | Mouse IgG |
HPAB-1408-FY | Mouse Anti-MST1R Recombinant Antibody (clone RON8) | ELISA, Inhib, WB | Mouse IgG |
HPAB-1409-FY | Mouse Anti-MST1R Recombinant Antibody (HPAB-1409-FY) | FC, ELISA | Mouse IgG |
HPAB-1410-FY | Mouse Anti-MST1R Recombinant Antibody (HPAB-1410-FY) | FC, ELISA, WB | Mouse IgG |
HPAB-1411-FY | Mouse Anti-MST1R Recombinant Antibody (HPAB-1411-FY) | FC, ELISA | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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