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Fab-arm Exchange Bispecific Antibody (FAE BsAb)

Creative Biolabs provides expert Fab-arm exchange (FAE) bispecific antibody (BsAb) generation service based on our in-depth knowledge of Fab-arm exchange. We provide FAE platform for the discovery and development of bispecific antibodies.


Figure: Diagram of Fab-arm exchange bispecific antibody (Nat Protoc, 2014)

There are three major steps for the generation of FAE bispecific antibody. Firstly, two IgG antibodies are separately expressed in mammalian cell lines. Meanwhile, a single residue mutation is introduced into the third constant (CH3) domain of each antibody. Then these antibodies are purified through standard protein recovery and purification procedures. Finally, bispecific antibody is produced by recombining of these two antibodies. Our FAE bispecific antibody has first-class quality with high yield (typically >95%) which can fully meet your demands.

Our FAE technology platform can also satisfy the requirement for large-scale manufacturing, which can generate at 0.5 kg/25 L scale. In addition, our FAE bispecific antibody products are stable for more than 15 months at 4°C.

Aran F Labrijn, et al. Controlled Fab-arm exchange for the generation of stable bispecific IgG1. Nat Protoc. 2014 Oct;9(10):2450-63.

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