MSLN
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Derivation: Mouse
Species Reactivity: Human
Type: Mouse Fab
Application: WB
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG
Application: WB
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG2a
Application: WB, ELISA, IHC
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse scFv
Application: WB
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Species Reactivity: Human
Type: Mouse antibody
Application: FC, IHC-Fr, WB
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Derivation: Phage display library screening
Species Reactivity: Human
Type: IgG
Application: WB
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Target: MSLN
Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
Drug: MMAF (monomethyl auristatin F)
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, FC
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Target: mesothelin
Linker: cleavable di-peptide linker
Drug: Duocarmycins
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Target: MSLN
Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
Drug: MMAE (monomethyl auristatin E)
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Target: mesothelin
Linker: disulfide
Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
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Target: MSLN
Linker: mc (maleimidocaproyl)
Drug: MMAF (monomethyl auristatin F)
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Species Reactivity: Mouse
Application: Cytotoxicity assay, Function study
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Target: mesothelin
Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Target: mesothelin
Species Reactivity: Human
Cytokine 1: IL12
Host: Mouse
Cytokine 1 Species: Human
Molecule Class: IL12-scFv
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Target: MSLN
Linker: protease-cleavable peptide linker
Drug: MMAE (Monomethyl auristatin E)
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Target: Mesothelin
Linker: Cleavable, disulfide
Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Species Reactivity: Human
Application: Cytotoxicity assay, Functional assay
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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For Research Use Only. Not For Clinical Use.