Products

Anti-EDB Immunocytokine, scFv (L19)-IL10 (ACFP-SH085)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB scFv to IL10. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of IL10. The fusion protein L19-IL10 displayed a therapeutic activity, which was superior to the activity of IL10 fused to an antibody of irrelevant specificity in the mouse. The fusion protein L19-IL10 might help overcome some of the clinical limitations of IL10 and provide a therapeutic benefit to patients with chronic inflammatory disorders, including arthritis. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.      

Specifications
Target
EDB
Molecule Class
scFv-IL10
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
L19
Related Disease
Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma
Cytokines 1
IL10
Cytokines 1 Description
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor 2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS
Entrez Gene ID
2335
UniProt ID
P02751

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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