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Creative Biolabs possesses unchallenged experience in synthesis of minibody and trimeric bispecific minibody (Tribi minibodies). Our experienced scientists are committed to providing custom synthesis strategy for your desired mini-antibody.

Minibody is composed of a pair of single-chain Fv fragments which are linked via CH3 domains, and Fvs with distinct specificity, which paired to the former part through heterodimerization process. To promote the heterodimerization efficiency, single-residue mutations can be introduced into each CH3 domains to achieve the “knobs and holes” approach. Far more than that, additional cysteine residues can also be introduced into CH3 domains to stabilize the bispecific minibody structure.


Figure: Diagram of the structure of minibody and Tribi minibody

As an enhanced version of minibody, Tribi minibody is an optimal tool in targeting tumor cells. One of its chains, which is designed to recognize tumor antigens via its two Fv fragments, while the other chain possessing a Fv fragment takes charge of recruiting effector cells, such as T cytotoxic cells or NK cells. With the addition of this extra binding domain, the avidity of Tribi minibody is significantly higher than that of the bispecific minibody. Thus, even at a lower concentration, Tribi minibody is still able to perform a stronger cytotoxicity than the corresponding bispecific minibody.

Taking advantage of its abundant resources in biotechnology, Creative Biolabs provides services not only a minibody or a Tribi minibody with high-affinity and confirmed cytotoxicity, but also integrated a budget and time-saving working procedure which can satisfy all of your requirements in every step.

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