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Orthogonal Fab bispecific antibody

Based on our unique antibody engineering platforms, Creative Biolabs provides world class orthogonal Fab bispecific antibodies (BsAbs). Our techniques combine structure-based design strategy with X-ray crystallography just in order to offer you a pure and well behaved bispecific antibody.


To avoid light and heavy chain mispairing, our experienced scientists create the heavy and the light chains within orthogonal Fab interfaces, which combine the use of computational modeling and X-ray crystallography. We can engineer mutations into Fab interfaces in order to minimize light chain and heavy chain mispairing and get correctly assembled products in one host cell. The advance of this novel technique is that it can overcome disadvantages of the two-host cell approach which has high cost and greatly complexity in production process. In addition, our scientists can produce orthogonal Fab interfaces using electrostatic steering which facilitates the efficient production of bispecific IgGs.

With years of experience, Creative Biolabs has designed a suitable and perfect strategy to greatly avoid light and heavy chain mispairing. Our scientists can provide you the bispecific heterodimeric IgGs with high quanlity to fit your needs.

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