Anti-Influenza Virus M2e Recombinant Antibody (TCN-032) (CAT#: TAB-508CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Influenza Virus M2e. TCN-032 is a human monoclonal antibody targeting a conserved epitope on M2e, was explored in experimental human influenza. TCN-032 may provide immediate immunity and therapeutic benefit in influenza A infection, with no apparent emergence of resistant virus. TCN-032 was safe with no evidence of immune exacerbation based on serum cytokine expression.
Specific Inquiry
FuncS
Figure 1 Therapeutic efficacy of anti-M2 mAbs TCN-031 and TCN-032 in mice.
Mice (n = 10) were infected by intranasal inoculation with 5 × LD₅₀ A/Vietnam/1203/04 (H5N1), followed by 3 i.p. injections with mAbs at 24, 72, and 120 h postinfection (a total of three mAb injections per mouse) and weighed daily for 14 d. Percentage-survival is shown.
Grandea, A. G., Olsen, O. A., Cox, T. C., Renshaw, M., Hammond, P. W., Chan-Hui, P. Y., ... & Pekosz, A. (2010). Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses. Proceedings of the National Academy of Sciences, 107(28), 12658-12663.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Influenza Virus
- Applications
- FuncS
- Related Disease
- Influenza
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Orthomyxoviruses; Influenza Virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-140 | Recombinant Mouse Anti-M2e Antibody (MAb148) | WB, ELISA, FuncS | IgG |
| PABX-140-F (E) | Recombinant Mouse Anti-M2e Antibody Fab Fragment (MAb148) | WB, ELISA, FuncS | Fab |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-508CL, RRID: AB_3111965)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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