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Blocking Antibody Products

The Crucial of Blocking Antibody Development

Blocking antibodies are essential tools in both clinical and experimental settings. By directly binding to their target molecules, they are able to prevent critical biological processes like cell adhesion or receptor-ligand interactions. This ability to interfere with harmful substances has significant clinical applications, as blocking antibodies can shield cells from damage. Given their important roles, it is essential to develop blocking antibodies with efficacy and safety.

Fig.1 Off-target T cell activation is prevented by CD18 blocking antibodies.Fig.1 CD18 blocking antibody prevents off-target T cell activation.1

Advantages of Blocking Antibody Compared with Neutralizing Antibody

While both blocking and neutralizing antibodies are powerful tools in immunology, blocking antibodies offer some distinct advantages:

  • Direct interference:
Blocking antibodies function by physically obstructing the target molecule, preventing it from interacting with other molecules. This direct interference can be more potent and immediate compared to the multi-step mechanisms of neutralizing antibodies.
  • Broad-spectrum activity:
Blocking antibodies can target a wider range of molecular interactions, including those involving cell adhesion, receptor-ligand binding, and enzyme activity. This broader spectrum of activity can be advantageous in treating diseases with complex mechanisms.
  • Potential for long-lasting effects:
By physically blocking the target molecule, blocking antibodies can have a longer-lasting effect compared to neutralizing antibodies, which may be more susceptible to viral mutations or immune evasion.
  • Versatility in therapeutic applications:
Blocking antibodies can be utilized for treating an extensive variety of conditions, including autoimmune disorders, cancer, and viral infections. Their ability to target specific molecular interactions makes them a valuable tool in precision medicine.

Our Blocking Antibody Production Service

Creative Biolabs provides a cost-effective blocking antibody production service to produce antibodies with blocking effect and safety. Our expert team leverages advanced techniques and cutting-edge technologies to deliver high-quality, custom-designed blocking antibodies tailored to your specific needs. From target antigen identification and immunization strategies to antibody screening, production, and rigorous characterization, we provide a seamless and efficient service. In addition, we provide a series of developed blocking antibody products, which are ready to use for customers' therapeutic development projects. Notably, we also deliver a special antibody function verification service to evaluate the blocking specificity and affinity of antibody products. At Creative Biolabs, our commitment to excellence ensures that you receive potent and specific blocking antibodies promptly to advance your scientific research.

Fig.2 Process. (Creative Biolabs Original)Fig.2 Our service process.

Popular Blocking Target Antigens

Target antigens are the specific molecules that a blocking antibody binds to and inhibits. Selecting the right target antigen is essential for developing effective blocking antibodies.

Receptors Ligands Cell Surface Markers Viral Proteins
EGFR, VEGFR, PD-1, FGF R, FDGFRα, etc. TNF-α, IL-6, PD-L1, VEGF-D, etc. CD20, CD3, CD4, CD8, CTLA-4, etc. Spike protein of SARS-CoV-2, envelope protein, hemagglutinin protein, neuraminidase protein, etc.

Highlight Features

  • Design and develop blocking antibodies that precisely target your specific antigen.
  • Flexible project scales from small-scale research to large-scale clinical trials.
  • Cutting-edge platforms and high-throughput screening.
  • Rigorous characterization to assess antibody properties.
  • Industry regulatory specifications-compliant facilities and processes.
  • Efficient project management to deliver your antibodies on time.

If you are looking for a reliable partner for high-quality blocking antibody production or a high-quality ready-to-use blocking antibody product, please feel free to get in touch with us immediately.

Reference
  1. Kauer, Joseph, et al. "CD18 antibody application blocks unwanted off-target T cell activation caused by bispecific antibodies." Cancers 13.18 (2021): 4596. Distributed under Open Access License CC BY 4.0, without modification.
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