Anti-Human MUC1 Recombinant Antibody (Gatipotuzumab) (CAT#: TAB-026ML)
Recombinant monoclonal antibody to MUC1. Gatipotuzumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.
Specific Inquiry
Stim
Figure 1 Impact of Gatipotuzumab and 4-Hydroxy-Tamoxifen (4-OHT) on OC viability.
Stimulation with Gatipotuzumab, 4-OHT and the combination of the two was performed in COV318, OV-90, SKOV-3, and OVCAR-3 cell lines over a 48-h and 72-h period. In general, Gatipotuzumab (Gati) alone only moderately reduced cell viability, while 4-OHT treatment appeared to be efficient in all the four cell lines tested (A-D). When viability of cells that had undergone co-stimulation was compared to that of those that had been treated with a single substance only, the overall net effect of co-stimulation was numerically slightly higher than the sum of individual effects of any of the two substances alone OVCAR-3 (C) and SKOV-3 (D). However, this was not statistically significant.
Heublein, S., Page, S., Mayr, D., Schmoeckel, E., Trillsch, F., Marmé, F.,... & Vattai, A. (2019). Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer. International journal of molecular sciences, 20(2), 295.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- IgG1, κ
- Specificity
- Human MUC1
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS, Stim
- Conjugate
- Unconjugated
- CAS
- 1264737-26-9
- Generic Name
- Gatipotuzumab
- UNII
- 85V55ZLV2Z
- Related Disease
- Solid tumors
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The MUC1 antibody has been reported in applications of ELISA, IHC, FC, IP, IF, FuncS, Stim.
Target
- Alternative Names
- Mucin 1; polymorphic epithelial mucin; PEM; episialin; CD227
- Gene ID
- 4582
- UniProt ID
- P15941
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Gatipotuzumab"
Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Gatipotuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to MUC1. Gatipotuzumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.
See other products for "MUC1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
| HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
| HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
| HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
Customer Reviews and Q&As
Customer Review
Q&As
-
Reliable in ELISA
We have been using Gatipotuzumab for ELISA, and it has provided consistent and reliable results. The optimal concentration was easy to determine, and the sensitivity is outstanding. -
High specificity in FC
Flow cytometry with Gatipotuzumab has been very efficient. The antibody labeled MUC1-expressing cancer cells with high specificity, which facilitated our analysis significantly. -
Minimal cross-reactivity
We noticed minimal cross-reactivity with non-human MUC1, which was expected but good to confirm. It's highly specific to human MUC1, as advertised.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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