Products

Anti-CD40 × Anti-CD28 Bispecific Antibody (TAND-L009)

Recombinant Anti-CD40 × Anti-CD28 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb can provoke increased T-cell–DC cluster formation. It was designed for the treatment of Acute myeloid leukaemic (AML).      

Specifications
Targets
CD40 & CD28
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
CD40
Host
Mouse
Clone
G28-5
Target 2
CD28
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Acute myeloid leukaemic (AML)
Targets
Target 1
CD40
Gene ID
958
UniProt ID
P25942
Alternative Names
p50; Bp50; CDW40; TNFRSF5
Target 2
CD28
Gene ID
940
UniProt ID
B4E0L1
Alternative Names
CD28; CD28 molecule; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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