Technology Approaches for Bispecific Antibody Development

As an undisputed global leader in antibody engineering and manufacturing, Creative Biolabs now provides a full range of services for bispecific antibody (BsAb) development by leveraging different technological approaches.

With two Fab arms in different epitope binding specificity, bispecific antibodies (BsAbs) are capable of bridging two different molecules (or cells) and thus mediating a recruitment of effector molecules (or cells) and drug delivery systems to targets, so as to improve the selectivity and efficacy of antibody-based treatments for human diseases, especially for oncotherapy. BsAbs consist of various formats, each of which can be crafted via biochemistry and molecular biology methods. Creative Biolabs supplies comprehensive technological approaches and solutions for BsAb development. With the capability to design, optimize different BsAbs and the capacity of manufacturing BsAbs from milligrams to grams scale, we can meet every customer’s requirements.

We offer a full range of technological approaches needed for bispecific antibody development:

• Genetic Engineering: combining the molecular design and recombinant antibody expression techniques to custom BsAbs in multiple formats
• Chemical Conjugation: utilizing suitable chemical crosslinkers to couple mAbs and antibody fragments
• Hybrid–hybridoma Technology: generating BsAbs based on fusion of two different hybridoma cell lines

For research use only. Not intended for any clinical use.