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Autoantibody Products

The Necessary of Further Research on Autoantibody

Autoantibodies are essential proteins that normally maintain cellular health, remove cellular debris, and regulate the immune system. While they serve as a crucial first line of defense against foreign pathogens, dysregulation of autoantibodies can lead to autoimmune disorders. In these circumstances, the immune system erroneously assaults the body's tissues, resulting in serious health concerns. As a result, further research is necessary to fully understand the complex role of autoantibodies in both health and disease, and to develop effective therapies for autoimmune conditions.

Fig.1 Multiple pathways lead to autoantibody-induced pathology.Fig.1 Autoantibody-induced pathology can occur via a variety of mechanisms.1

Potential Therapeutic Benefits of Autoantibodies

Autoantibodies, when engineered and administered therapeutically, offer several advantages:

High Specificity Potent Efficacy Long Duration of Action
Autoantibodies can be designed to bind with exquisite precision to target molecules, minimizing off-target effects and reducing adverse reactions. They can elicit robust biological responses, such as neutralizing harmful proteins or stimulating immune cells to attack diseased cells. Engineered autoantibodies can possess extended half-lives, enabling less frequent dosing and improved patient compliance.
Versatility Targeted Delivery Synergistic Effects
Autoantibodies can be adjusted to treat a variety of illnesses involving cancer, autoimmune disorders, and infectious diseases. Autoantibodies can deliver therapeutic payloads directly to sick cells, lowering overall toxicity. Autoantibodies can be used in conjunction with other therapeutic options to improve therapy effectiveness.

Autoantibody Production Service at Creative Biolabs

Creative Biolabs offers a comprehensive autoantibody production service, providing researchers with tailored solutions for generating specific autoantibodies. Our service encompasses autoantibody sequence optimization, gene synthesis, vector construction, antibody expression, purification, and in-depth characterization. Furthermore, we are capable of producing autoantibodies based on customer-selected antigens. Throughout the process, we employ stringent quality control techniques to assure the quality and efficacy of your autoantibody products.

Notably, our versatile antibody production services are compatible with numerous antibody formats, such as intrabody, pH-sensitive antibodies, agonist antibodies, etc. Our seasoned scientists have the ability to customize the antibody production service process to cater to your diverse needs (quantity, formats, etc.). Leveraging advanced technologies and experienced scientists, we empower researchers to accelerate your autoimmune disease research and drug discovery efforts.

Available Autoantibody Types

Here are some types of autoantibodies that are commonly produced in laboratories:

  • Antinuclear Antibodies (ANA)
  • Anti-mitochondrial Antibodies (AMA)
  • Anti-neutrophil Cytoplasmic Antibodies (ANCA)
  • Anti-double-stranded DNA (dsDNA) Antibodies
  • Anti-phospholipid Antibodies (APA)
  • Anti-smooth Muscle Antibodies (ASMA)
  • Anti-thyroid Antibodies
  • Anti-tissue Transglutaminase Antibodies (Anti-tTG)

Targets Involved in Autoantibodies

  • Insulin and Insulin Receptors
  • Collagen and Other Extracellular Matrix Proteins
  • Thyroid Hormone Receptors and Thyroglobulin
  • Muscle Proteins (e.g., Myosin, Actin)
  • Nuclear Antigens (e.g., DNA, Histones)
  • Cytokines and Inflammatory Mediators
  • Neuronal Proteins and Synaptic Components
  • Endothelial Cell Proteins
  • Platelet-derived Proteins

Features of Our Autoantibody Production Service

  • Customized autoantibody production service.
  • Comprehensive characterization to enable autoantibody products' high quality.
  • Adaptable autoantibody production.
  • Robust platforms equipped with cutting-edge facilities and technologies.
  • Rigorous quality control measures.
  • Time-saving projects set up.

Are you looking for a smart autoantibody product or a specialized production service supplier? Please don't hesitate to contact us if you are interested in our autoantibody production service.

Reference
  1. Ludwig, Ralf J., et al. "Mechanisms of autoantibody-induced pathology." Frontiers in Immunology 8 (2017): 603. Distributed under Open Access License CC BY 4.0, without modification.
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