Creative Biolabs is one of the first-in class global manufacturers of immunotoxins and is professional in producing all kinds of immunotoxins. Based on our advanced techniques and rich experiment, we have developed and optimized a novel platform of immunotoxins production. Compared to traditional expression system, High-Exp™ enhances immunotoxins protein expression over 10 folds.
Immunotoxin is a human-made protein that consists of a targeting portion linked to a toxin. When the protein binds to that cell, it is taken in through endocytosis, and the toxin kills the cell. The toxin is usually a cytotoxic protein derived from a bacterial or plant protein, such as Diphtheria toxin (DT), Cholera toxin (CT), Trichosanthin (TCS), Dianthin etc.. The antibody transports the toxin in the body and selectively targets it to tumor cells by binding to a cell-surface antigen. The toxin then enters the cell and incapacitates it by irreversibly blocking an essential metabolic process. As it has little harm to normal tissues, it is vividly called "the biological missiles".
Generally, CHO cell line is widely used in immunotoxins production. But the problems of low expression level, low stabilization and apoptosis have long plagued scientists. Hence, relying on the outstanding academic group and profound expertise, Creative Biolabs has developed High-Exp™ platform that can promote the expression level, stability and anti-apoptosis capability of immunotoxins production.
Our High-Exp™ platform can be tailor-designed to meet your specific needs and it is fast, reliable and affordable. If you are interested in using the platform to support your development program, please contact us by sending us your detailed request to e-mail. Based on the quantity and quality requirement of your request, we will connect you as soon as possible.
See a full list of our Immunotoxin Products.