As an undisputed global leader in the field of antibody-drug conjugate (ADC) developing and manufacture, Creative Biolabs assembles a strong team with experienced Ph.D level scientists, well trained technicians, ADC specialist to offer a full range of capabilities to help customers solve complex ADC analysis problems. We are committed to assisting our customers to achieve accurate assay data and make better ADC optimization decisions in a time-saving and cost-effective way.
As is well-known, cancer represents one of the greatest threats to public health in the whole world and is a major area of focus for the pharmaceutical industry. However, traditional chemotherapy drugs have harsh side effects on most cancer patients because they attack not only malignant cells, but other healthy, fast-growing cells in the patient’s body. Antibody-drug conjugates (ADCs) are an emerging class of ideal cancer therapeutics to deliver cytotoxic drug to the tumor tissue. They have shown great promise in treating a variety of cancer patients with the goal of minimizing the severe side effects of conventional chemotherapy. Utilizing the tumor targeting potential of monoclonal antibodies, ADCs deliver highly potent cytotoxic drugs predominantly to the tumor cells. In addition to the presence of three vastly different components including monoclonal antibodies, cytotoxic drugs and linkage technologies, various conjugation processes employed to attach the payloads to the antibody are involved in the development of ADCs, resulting in the diversity, complexity and heterogeneity of ADC structures, simultaneously, increasing the difficulty of analyzing the ADC molecules. However, there is no analytical ‘industry standard’ that can be applied to all ADC molecules yet. According to the complex nature of ADC, scientists from Creative Biolabs will design custom bioanalytical strategies along with the well established methods for therapeutic antibodies and cytotoxic drugs to meet your ADC development and optimization goals in a timely manner for market launch. Based on you specific ADC feature, multiple analytical platforms from Creative Biolabs can be elaborately integrated to provide a comprehensive characterization of the biophysical and biochemical properties, in vitro and in vivo stability of linker and drug species, ADME (the absorption, distribution, metabolism, and excretion properties of ADC) and PK characters, drug load distribution and DAR (drug to antibody ratio) which are extremely crucial for the safety and therapeutic efficacy of a successful ADC.
With the availability of various analytical techniques, certified technical staff and numerous state-of-the-art instruments, Creative Biolabs is capable of providing customers the most scientific and reliable ADC assay services for each project. We will present and deliver a comprehensive report including detailed procedures and results for the assessment of your ADC molecules, which contains analytical methods, protocols when applicable, all test results, appropriate graphs and calculations, and sample raw data is also available upon request. Creative Biolabs strives to retain customers through strong communication, timeliness and responsive ADC analysis program.