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Anti-VEGF × Anti-HER2 Bispecific Antibody (TAND-L013)

Recombinant Anti-VEGF × Anti-HER2 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. It was designed for the treatment of colorectal tumor, breast cancer, lung cancer, renal cell carcinoma, glioma, glioblastoma and ovarian cancer.      

Specifications
Targets
VEGF & HER2
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
VEGF
Host
Human
Target 2
HER2
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Colorectal tumor, Breast cancer, Lung cancer, Renal cell carcinoma, Glioma, Glioblastoma, Ovarian cancer
Targets
Target 1
VEGF
Gene ID
7422
UniProt ID
P15692
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
Target 2
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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