AAV9 VP1

The adeno-associated viruses (AAVs), single-stranded DNA packaging viruses belonging to the Parvoviridae family, are promising vectors for gene delivery. There are over 100 AAV genomic isolates, and 13 human and nonhuman serotypes have been described. To date, no diseases have been associated with AAV infections. Recombinant AAV (rAAV) vectors can package foreign (nonviral) genes, transduce both dividing and nondividing cells, and induce long-term gene expression in nondividing cells. In addition, AAV serotypes have different transduction efficiencies for different tissues dictated by their capsid sequence. These properties make AAVs desirable vectors for therapeutic gene delivery. Unique AAV9-mediated transduction properties for crossing blood-brain barrier made it possible for gene therapy against neuro-diseases.