Human disease related genes
Intracellular
Cell type enhanced (Microglial cells, Adipocytes)
Low immune cell specificity
Low cell line specificity
Forms homooligomers(PubMed:10880512). Interacts with RIPK2 (PubMed:10880512, PubMed:17054981). Interacts with ARHGEF2 (PubMed:19043560). Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection (PubMed:22672233). Interacts with RNF34 (PubMed:25012219). Interacts with IFIH1; this interaction promotes transcription of antiviral genes and inhibition of viral replication (PubMed:32169843).
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For Research Use Only. Not For Clinical Use.