Disease related genes, Human disease related genes, Nuclear receptors, Transcription factors
Intracellular
Cell type enriched (Rod photoreceptor cells)
Not detected in immune cells
Not detected
Homodimer. Interacts with PIAS3; the interaction sumoylates NR2E3 and promotes repression of cone-specific gene transcription and activation of rod-specific genes (By similarity). Component of a complex that includes NR2E3, PIAS3, NRL, CRX and/or NR1D1. Binds NR1D1. Binds directly in the complex with CRX, PIAS3 and NR1D1 (By similarity). Interacts (via the DNA-binding domain) with CRX (via its DNA binding domain); the interaction represses S- and M-cone opsin expression.
DNA-binding, Receptor, Repressor
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For Research Use Only. Not For Clinical Use.