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Rpn2
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Metabolic proteins, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the oligosaccharyltransferase (OST) complex (PubMed:31831667). OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits (PubMed:23606741, PubMed:25135935, PubMed:31831667). STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with DDI2 (PubMed:29290612). Interacts with TMEM35A/NACHO (By similarity).
More Types Infomation
- PE-H2-Q10/Mouse Rpn2 (VGITNVDL) MHC Tetramer (MHC-LC881)
-
- Class: Class I
- Antigen: Rpn2
- Antigen Species: Mouse
- Peptide: VGITNVDL
- Conjugate: PE
- APC-H2-Q10/Mouse Rpn2 (VGITNVDL) MHC Tetramer (MHC-LC882)
-
- Class: Class I
- Antigen: Rpn2
- Antigen Species: Mouse
- Peptide: VGITNVDL
- Conjugate: APC
- BV421-H2-Q10/Mouse Rpn2 (VGITNVDL) MHC Tetramer (MHC-LC883)
-
- Class: Class I
- Antigen: Rpn2
- Antigen Species: Mouse
- Peptide: VGITNVDL
- Conjugate: BV421
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For Research Use Only. Not For Clinical Use.