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HTRA3
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
Protein class
Enzymes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Fibroblasts, Skeletal myocytes, Leydig cells, Peritubular cells, Theca cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (U-2197)
Interaction
Homotrimer (PubMed:26110759). Interacts with TGFB1; the interaction inhibits TGFB-mediated signaling. Interacts with BMP4; the interaction inhibits BMP4-mediated signaling. Interacts with TGFB2 and GDF5 (By similarity). Interacts with MYH9.
Molecular function
Hydrolase, Protease, Serine protease
More Types Infomation
- Recombinant Anti-Human HTRA3 Antibody (MOB-3005z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, Neut, FuncS
- Recombinant Anti-Human HTRA3 Antibody scFv Fragment (MOB-3005z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, IHC, FuncS
- Recombinant Anti-Human HTRA3 Antibody Fab Fragment (MOB-3005z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: FC, Neut, Funcs
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For Research Use Only. Not For Clinical Use.