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KLK7
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at 14-Tyr- -Gln-15 and insulin B chain at 6-Leu- -Cys-7, 16-Tyr- -Leu-17, 25-Phe- -Tyr-26 and 26-Tyr- -Thr-27. Could play a role in the activation of precursors to inflammatory cytokines.
Protein class
Cancer-related genes, Enzymes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes, Breast myoepithelial cells, Breast glandular cells, Alveolar cells type 1, Squamous epithelial cells, Basal keratinocytes, Basal squamous epithelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A-431, CAPAN-2, HaCaT)
Molecular function
Hydrolase, Protease, Serine protease
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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- Species Reactivity: Mouse
- Type: IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: Neut, WB
- Recombinant Mouse Anti-KLK7 Antibody (CBL131) (NEUT-1653CQ)
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- Species Reactivity: Human
- Type: IgG2
- Application: Neut, WB
- Recombinant Mouse Anti-KLK7 Antibody (MM0433-5J28) (NEUT-1652CQ)
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- Species Reactivity: Human
- Type: IgG1
- Application: WB, Neut
- Recombinant Mouse Anti-KLK7 Antibody (CBL613) (NEUT-1651CQ)
-
- Species Reactivity: Human
- Type: IgG2a
- Application: WB, IP, Neut
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For Research Use Only. Not For Clinical Use.