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PMAIP1

This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes, Urothelial cells, Glandular and luminal cells, Squamous epithelial cells, Endometrial ciliated cells)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Cell line enhanced (GAMG, U-138 MG)

Interaction

Interacts with MCL1 (PubMed:15694340, 17374615, 17389404). Interacts with BCL2A1 (Ref. 11). Interacts with BAX (PubMed:15705586). Interacts with BCL2L10 (PubMed:23563182).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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